21038-67-5

Basic information

• Product Name: PYRIDO[3,4-D]PYRIMIDINE-2,4(1H,3H)-DIONE
• Synonyms: PYRIDO[3,4-D]PYRIMIDINE-2,4(1H,3H)-DIONE;1H,2H,3H,4H-pyrido[2,3-d]pyriMidine-2,4-dione;pyrido[3,4-d]pyriMidine-2,4-diol;2,4-Dihydroxypyrido[3,4-d]pyrimidine;1H-pyrido[3,4-d]pyrimidine-2,4-dione
• CAS NO: 21038-67-5
• Molecular Formula: C7H5N3O2
• Molecular Weight: 163.13
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 21038-67-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: >320 °C
• Appearance: /
• Density: 1.424 g/cm³
• Refractive Index: 1.593
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.01±0.20(Predicted)
• CAS DataBase Reference: PYRIDO[3,4-D]PYRIMIDINE-2,4(1H,3H)-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDO[3,4-D]PYRIMIDINE-2,4(1H,3H)-DIONE(21038-67-5)
• EPA Substance Registry System: PYRIDO[3,4-D]PYRIMIDINE-2,4(1H,3H)-DIONE(21038-67-5)

Safety Data

• Hazardous Substances Data: 21038-67-5(Hazardous Substances Data)

Usage

General Description

Pyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione, also known as allopurinol, is a medication used to prevent gout and certain types of kidney stones. It works by decreasing the production of uric acid in the body. Uric acid buildup can lead to gout or kidney stones. Allopurinol is a xanthine oxidase inhibitor, which means it inhibits the enzyme that is responsible for the production of uric acid. By reducing uric acid levels in the body, allopurinol can help prevent the painful symptoms associated with gout and kidney stones. It is usually taken orally and is available in tablet form. It may also be used to prevent high uric acid levels in patients receiving cancer chemotherapy. Like any medication, allopurinol may have side effects and should be used under the supervision of a healthcare professional.

InChI:InChI=1/C7H5N3O2/c11-6-4-1-2-8-3-5(4)9-7(12)10-6/h1-3H,(H2,9,10,11,12)

Upstream product

• 4663-98-3 pyridine-3,4-dicarboxamide 
• 57-13-6 urea 
• 7726-95-6 bromine 
• 64188-97-2 3-aminopyridine-4-carboxamide 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 124-38-9 carbon dioxide 
• 78790-79-1 3-amino-4-cyano-pyridine 
• 7579-20-6 3-Aminopyridine-4-carboxylic acid 

Downstream Products

• 908240-50-6 2,4-dichloropyrido[3,4-d]pyrimidine 

Relevant articles and documents

METHODS AND COMPOSITIONS FOR OCULAR CELL THERAPY

The present invention provides ocular cells, genetically modified by a CRISPR system targeting the expression of B2M for ocular cell therapy. The invention further provides methods of generating an expanded population of genetically modified ocular cells, for example limbal stem cells (LSCs) or corneal endothelial cells (CECs), wherein the cells are expanded involving the use of a LATS inhibitor and the expression of B2M in the cells has been reduced or eliminated. The present invention also provides cell populations, preparations, uses and methods of therapy comprising said cells.

6-6 FUSED BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS LATS INHIBITORS

The present invention is related to 6-6 Fused Bicyclic Heteroaryl Compounds of the Formula A2 or A1 and their Use as LATS Inhibitors, or a salt, stereoisomer or pharmaceutical composition thereof; wherein the variables are as defined herein (A1 and A2). The present invention further relates to a method of LATS inhibition in a cell population using a compound of Formula A1, or a salt, stereoisomer or pharmaceutical composition thereof. The present invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, their use in the treatment and management of diseases or disorders.

Ionic liquid promoted synthesis of heterocycle-fused pyrimidine-2,4(1H,3H)-diones utilising CO2

An efficient ionic liquid system was developed for the preparation of various heterocycle-fused pyrimidine-2, 4(1H,3H)-diones in moderate to excellent yields (52–95%). It was found that [HDBN+][TFE?], a simple and easily prepared ionic liquid, could act as both the solvent and reaction promoter, and that the reactions could be efficiently carried out at atmospheric pressures of CO2.