210530-71-5

Basic information

• Product Name: 3,4-DIFLUOROPHENYLACETIC ACID METHYL ESTER
• Synonyms: 3,4-DIFLUOROPHENYLACETIC ACID METHYL ESTER;3,4-difluoro acetate;Methyl 2-(3,4-difluorophenyl)acetate
• CAS NO: 210530-71-5
• Molecular Formula: C₉H₈F₂O₂
• Molecular Weight: 186.16
• Mol File: 210530-71-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 211°C at 760 mmHg
• Flash Point: 79.4°C
• Appearance: /
• Density: 1.235g/cm³
• Vapor Pressure: 0.187mmHg at 25°C
• Refractive Index: 1.472
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3,4-DIFLUOROPHENYLACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIFLUOROPHENYLACETIC ACID METHYL ESTER(210530-71-5)
• EPA Substance Registry System: 3,4-DIFLUOROPHENYLACETIC ACID METHYL ESTER(210530-71-5)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 210530-71-5(Hazardous Substances Data)

Usage

General Description

3,4-Difluorophenylacetic Acid Methyl Ester is a chemical compound that belongs to the category of aromatic compounds, specifically fluorinated benzene derivatives and acetate esters. This synthetic compound is an organic structure composed of a phenyl group with two fluorine atoms at the 3rd and 4th positions. Its ester form indicates an intrinsic presence of a carboxylic acid (acetic acid) which is esterified with a methyl group. While there is limited information on its practical applications or properties, this compound may be used in various research and development or chemical production contexts due to its distinct molecular structure. However, like many chemicals, it should be appropriately handled and stored to ensure safety and prevent any potential harm.

InChI:InChI=1/C9H8F2O2/c1-13-9(12)5-6-2-3-7(10)8(11)4-6/h2-4H,5H2,1H3

Upstream product

• 67-56-1 methanol 
• 658-93-5 (3,4-difluorophenyl)acetic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 619323-21-6 methyl 2-(3,4-difluorophenyl)pent-4-enoate 
• 619323-50-1 3-(3,4-difluorophenyl)-5-methyltetrahydrofuran-2-one 
• 619323-37-4 2-(3,4-difluorophenyl)pent-4-enoic acid 
• 476472-54-5 2-(3,4-difluoro-phenyl)-1-(6-methyl-pyridin-2-yl)-ethanone 
• 741682-83-7 C₁₁H₁₀F₂O₂ 
• 306761-16-0 methyl 2-methyl-2-(3,4-difluorophenyl)propionate 
• 557798-56-8 methyl 2-bromo-2-(3,4-difluorophenyl)acetate 
• 300356-37-0 3-cyclopentyl-2-(3,4-difluorophenyl)propionic acid methyl ester 
• 949167-80-0 1-amino-3-(3,4-difluorophenyl)piperidin-2-one 
• 797784-35-1 2-(3,4-difluorophenyl)-acetic hydrazide 
• 1227845-44-4 N'-[2-(3,4-Difluorophenyl)acetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide 
• 1227845-76-2 N'-[2-(3,4-difluorophenyl)acetyl]-2-ethyl-4-methoxy-3-methyl-benzohydrazide 

Relevant articles and documents

PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES AS A2A RECEPTOR ANTAGONIST

Disclosed herein is a pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as A2A receptor antagonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as A2A receptor antagonist.

Discovery, structure-activity relationships, pharmacokinetics, and efficacy of glucokinase activator (2 R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)-N- thiazol-2-yl-propionamide (RO0281675)

Glucokinase (GK) is a glucose sensor that couples glucose metabolism to insulin release. The important role of GK in maintaining glucose homeostasis is illustrated in patients with GK mutations. In this publication, identification of the hit molecule 1 and its SAR development, which led to the discovery of potent allosteric GK activators 9a and 21a, is described. Compound 21a (RO0281675) was used to validate the clinical relevance of targeting GK to treat type 2 diabetes.

HETEROAROMATIC GLUCOKINASE ACTIVATORS

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