211501-32-5

Basic information

• Product Name: (R)-2-[2-(2,5-difluorophenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione
• Synonyms: (R)-2-[2-(2,5-difluorophenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione
• CAS NO: 211501-32-5
• Molecular Weight: 317.292
• Mol File: 211501-32-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-2-[2-(2,5-difluorophenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-[2-(2,5-difluorophenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione(211501-32-5)
• EPA Substance Registry System: (R)-2-[2-(2,5-difluorophenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione(211501-32-5)

Safety Data

• Hazardous Substances Data: 211501-32-5(Hazardous Substances Data)

Upstream product

• 2713-31-7 2,5-difluorophenol 
• 73323-91-8 (1'R)-N-(1'-hydroxyethyl-2'-methyl)-1H-isoindole-1,3(2H)-dione 
• 1972-28-7 diethylazodicarboxylate 

Downstream Products

• 747393-55-1 (R)-3-[(2,5-difluorophenyl)oxy]propyl-2-amine 
• 211501-33-6 (R)-1-(2,5-difluorophenoxy)-2-propanamine hydrochloride 

Relevant articles and documents

Fungicidal amides

Compounds of Formula I are disclosed which are useful as fungicides wherein R1is hydrogen; halogen; C1-C2alkoxy; C1-C2haloalkoxy; cyano; or C1-C2alkyl optionally substituted with halogen, C1-C2alkoxy or cyano; R2is hydrogen; halogen; or C1-C4alkyl optionally substituted with halogen, C1-C2alkoxy or cyano; R3is hydrogen; halogen; C1-C4alkoxy; C1-C4haloalkoxy; or C1-C4alkyl optionally substituted with halogen, C1-C2alkoxy or cyano; or R2and R3can be taken together as —CH2CH2—; R4is C1-C2alkyl; R5is R6, CH(R8)OR6, CH(R8)CH(R7)R6or C(R8)═C(R7)R6; and R6, R7and R8are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and a method for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound of Formula I.

Design of scytalone dehydratase inhibitors as rice blast fungicides: (N- phenoxypropyl)-carboxamides

Insights gained from a crystal structure of scytalone dehydratase led to the design of carboxamide inhibitors with a phenoxypropyl group substituted on the nitrogen atom. Potent enzyme inhibitors were synthesized around this motif, the best of which provided excellent control of rice blast disease in greenhouse assays and outdoor field trials.