21168-71-8

Basic information

• Product Name: C-(1-ETHYL-PIPERIDIN-4-YL)-METHYLAMINE
• Synonyms: 1-(1-ethylpiperidin-4-yl)MethanaMine;1-Ethyl-4-(aminomethyl)piperidine;1-Ethyl-4-piperidinemethanamine;(1-ethyl-4-piperidyl)methanamine;C-(1-ETHYL-PIPERIDIN-4-YL)-METHYLAMINE;(1-ETHYL-4-PIPERIDINYL)METHANAMINE;(1-Ethyl-4-piperidinyl)methaneamine;C-(1-Ethyl-piperidin-4-yl)-methylaminedihydrochloride
• CAS NO: 21168-71-8
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.24
• Mol File: 21168-71-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 87 °C
• Flash Point: 66.325°C
• Appearance: /
• Density: 0.89g/cm³
• Vapor Pressure: 0.569mmHg at 25°C
• Refractive Index: 1.465
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: C-(1-ETHYL-PIPERIDIN-4-YL)-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: C-(1-ETHYL-PIPERIDIN-4-YL)-METHYLAMINE(21168-71-8)
• EPA Substance Registry System: C-(1-ETHYL-PIPERIDIN-4-YL)-METHYLAMINE(21168-71-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• Hazardous Substances Data: 21168-71-8(Hazardous Substances Data)

Usage

General Description

C-(1-Ethyl-piperidin-4-yl)-methylamine is a chemical compound with the molecular formula C10H20N2. It is a primary amine and a derivative of piperidine, with a methyl group attached to the nitrogen atom of the piperidine ring. C-(1-ETHYL-PIPERIDIN-4-YL)-METHYLAMINE is used in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It can also be used as an intermediate in the synthesis of other organic compounds. C-(1-Ethyl-piperidin-4-yl)-methylamine is a clear, colorless liquid with a faint odor, and it should be handled with care due to its potential health and safety hazards.

InChI:InChI=1/C8H18N2/c1-2-10-5-3-8(7-9)4-6-10/h8H,2-7,9H2,1H3

Upstream product

• 77445-06-8 1-acetyl-4-aminomethylpiperidine 

Downstream Products

• 76005-21-5 N⁴-(3,5-Dichloro-phenyl)-N²-(1-ethyl-piperidin-4-ylmethyl)-quinazoline-2,4-diamine; hydrochloride 
• 76005-20-4 N⁴-(3,4-Dichloro-phenyl)-N²-(1-ethyl-piperidin-4-ylmethyl)-quinazoline-2,4-diamine; hydrochloride 
• 76004-58-5 N²-(3,4-Dichloro-phenyl)-N⁴-(1-ethyl-piperidin-4-ylmethyl)-quinazoline-2,4-diamine; hydrochloride 
• 76005-22-6 N²-(1-Ethyl-piperidin-4-ylmethyl)-N⁴-(4-trifluoromethyl-phenyl)-quinazoline-2,4-diamine; hydrochloride 
• 1347636-13-8 1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-(1-ethylpiperidin-4-yl)methylcarbamoylmethylindole oxalate 
• 1025065-79-5 N-((1-ethylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)-imidazo[1,2-b]pyridazin-6-amine 
• 1025065-78-4 N-((1-ethylpiperidin-4-yl)methyl)-7-methyl-3-(3-(trifluoromethoxy)phenyl)-imidazo[1,2-b]pyridazin-6-amine 
• 1192166-28-1 4-(8-Dimethylamino-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-N-(1-ethyl-piperidin-4-ylmethyl)-3-methoxy-benzamide 
• 1266620-21-6 C₁₆H₂₁ClFN₃O₂ 
• 1331742-47-2 C₂₀H₂₃F₃N₆O 

Relevant articles and documents

Synthesis and pharmacological evaluation of carboxamide derivatives as selective serotoninergic 5-HT4 receptor agonists

A number of new carboxamide derivatives were synthesized. The affinity of these compounds for the serotoninergic 5-HT4 receptor was evaluated by use of radioligand-binding techniques. The agonistic activity was evaluated as the contractile effect of the ascending colon isolated from guinea-pigs. Among these compounds, 4-amino-5-chloro-2-methoxy-N-[l-[2- [(methylsulfonyl)amino]ethly]-4piperidinylmethyl]benzamide (24) showed a high affinity for the 5-HT4 receptor (Ki = 9.6 nM). Compound 24 displayed a higher affinity for 5-HT4 receptors than the other receptors, including, 5- HT3 and dopamine D2 receptors. In addition, compound 24 was confirmed to be a potent 5-HT4 receptor agonist (ED50 = 7.0 nM). An interaction model between compound 24 and 5-HT4 receptor was proposed.

Indoles

A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: wherein A, B, C, D, T, Y, and Z each represent a methine or a nitrogen linkage; R1, R2, R3, R4, and R5 each represent a substituent; n represents 0 or an integer of 1 to 3; m represents 0 or an integer of 1 to 6; and p represents an integer of 1 to 3. The compounds have serotonin antagonism. They are therefore clinically useful as medicaments, in particular, for treating, ameliorating, and preventing spastic paralysis. They are also useful as central muscle relaxants for ameliorating myotonia.