21169-71-1 Usage
Description
Isoxazole-5-carboxylic acid is an organic compound that can be synthesized through various chemical reactions. It is a slightly yellow powder and is known for its role in the synthesis and reactivity of isoxazoles. Isoxazole-5-carboxylic acid is particularly useful in the development of pharmaceuticals, as it participates in the synthesis of acylguanidine FXa inhibitors, which are crucial in the treatment of various medical conditions.
Uses
Used in Pharmaceutical Industry:
Isoxazole-5-carboxylic acid is used as a key intermediate in the synthesis of acylguanidine FXa inhibitors for the pharmaceutical industry. These inhibitors play a vital role in the treatment of various medical conditions, such as blood clotting disorders and other related health issues. The compound's ability to participate in the synthesis process makes it a valuable asset in the development of new and effective medications.
Used in Chemical Synthesis:
Isoxazole-5-carboxylic acid is also used as a reagent in the synthesis of various chemical compounds. Its unique properties allow it to be involved in conjugate addition reactions, which are essential in the formation of isoxazole-5-carboxylic acid derivatives. These derivatives can be further utilized in the development of new chemicals and materials with potential applications in various industries.
Used in Research and Development:
Isoxazole-5-carboxylic acid is employed as a research compound in the study of isoxazoles and their chemical properties. Its involvement in the synthesis and reactivity of isoxazoles makes it an important tool for scientists and researchers working on the development of new compounds and materials. The compound's versatility in chemical reactions allows researchers to explore its potential applications in various fields, including pharmaceuticals, materials science, and more.
Check Digit Verification of cas no
The CAS Registry Mumber 21169-71-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,1,6 and 9 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 21169-71:
(7*2)+(6*1)+(5*1)+(4*6)+(3*9)+(2*7)+(1*1)=91
91 % 10 = 1
So 21169-71-1 is a valid CAS Registry Number.
InChI:InChI=1/C4H3NO3/c6-4(7)3-1-2-5-8-3/h1-2H,(H,6,7)
21169-71-1Relevant articles and documents
A simple synthesis of isoxazole-5-carboxylic acid
Spiegler,Gotz
, p. 69 - 70 (1986)
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Carboxylation of C-H bonds using N -heterocyclic carbene gold(I) complexes
Boogaerts, Ine I. F.,Nolan, Steven P.
supporting information; experimental part, p. 8858 - 8859 (2010/08/21)
A highly efficient [(NHC)AuI]-based (NHC = N-heterocyclic carbene) catalytic system for the carboxylation of aromatic and heteroaromatic C-H bonds was developed. The significant base strength of the Au-OH species is at the origin of the activation process and permits the facile functionalization of C-H bonds without the use of other organometallic reagents.
Chemical oxidation of an anticonvulsant N-(5'-methylisoxazol-3-yl) 2,6- dimethylbenzamide (D2916)
Adolphe-Pierre,Menager,Tombret,Verite,Lepage,Lafont
, p. 513 - 518 (2007/10/03)
The new anticonvulsant N-(5'-methylisoxazol-3-yl)-2,6-dimethylbeazamide (D2916), which presents two kinds of methyl groups which could be oxidized, was submitted to various chemical oxidizing agents. Several sites and degrees of oxidation were observed. The main oxidized site was the arylmethyl group without cleavage of the isoxazole ring, leading via carboxylic acid and primary alcohol intermediates to phthalimide and lactame derivatives. In no case was the methyl group of the isoxazole moiety hydroxylated.
