21170-34-3Relevant articles and documents
4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors
Dexheimer, Thomas S.,Gediya, Lalji K.,Stephen, Andrew G.,Weidlich, Iwona,Antony, Smitha,Marchand, Christophe,Interthal, Heidrun,Nicklaus, Marc,Fisher, Robert J.,Njar, Vincent C.,Pommier, Yves
experimental part, p. 7122 - 7131 (2010/04/28)
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an enzyme that catalyzes the hydrolysis of 3′-phosphotyrosyl bonds. Such linkages form in vivo when topoisomerase I (Top1) processes DNA. For this reason, Tdp1 has been implicated in the repair of irreversible Top