211820-01-8Relevant articles and documents
Novel 4-piperidinopyridine inhibitors of oxidosqualene cyclase-lanosterol synthase derived by consideration of inhibitor pKa
Brown, George R.,Foubister, Alan J.,Johnson, Michael C.,Newcombe, Nicholas J.,Waterson, David,Wells, Stuart L.
, p. 2213 - 2216 (2001)
Potent inhibition of rat microsomal oxidosqualene cyclase-lanosterol synthase (OSC) was maintained after structural modification of the 4-piperidinopyridine OSC inhibitor series. These novel analogues with a much lower pKa range (5.8-6.7) gave