21215-62-3 Usage
Description
CALCITONIN, HUMAN is a bioactive peptide hormone that plays a crucial role in regulating calcium homeostasis in the body. It is derived from the calcitonin gene and is primarily produced by the parafollicular cells (C cells) of the thyroid gland. CALCITONIN, HUMAN is known for its ability to decrease blood calcium and phosphate levels by inhibiting the resorption of these minerals by osteoblasts and osteocytes. Additionally, it acts as a carrier peptide that can be used to internalize fusion proteins, making it a valuable tool in various research and therapeutic applications.
Uses
Used in Pharmaceutical Industry:
CALCITONIN, HUMAN is used as a therapeutic agent for the treatment of conditions characterized by abnormally high levels of calcium in the blood, such as hypercalcemia and osteoporosis. It helps to reduce the rate of bone resorption, thereby decreasing the release of calcium from the bones into the bloodstream.
CALCITONIN, HUMAN is also used as a research tool to study its ability to stimulate cyclic adenosine monophosphate (cAMP) production post transfection in mammalian cells. This is achieved by activating the human CALCRL (calcitonin receptor-like receptor gene), receptor activity-modifying protein 1 (RAMP1), and CTR (calcitonin receptor), which are essential for understanding the molecular mechanisms underlying CALCITONIN's actions.
Used in Research and Development:
CALCITONIN, HUMAN serves as an important research tool for studying the regulation of calcium homeostasis and bone metabolism. It is used in various in vitro and in vivo experiments to investigate the effects of CALCITONIN on bone cells, as well as its potential role in the treatment of bone-related disorders.
Brand Name:
CALCITONIN, HUMAN is available under the brand name Calcimar, which is manufactured by Rhone-Poulenc Rorer. This brand is specifically formulated for the treatment of conditions associated with elevated calcium levels in the body.
Biochem/physiol Actions
Calcitonin, also referred to as thyrocalcitonin, is a 32 amino acid peptide hormone, which is present abundantly in seminal plasma compared to serum. It acts as a first messenger and hence regulates the the production of cAMP as well as mammalian sperm function. It also facilitates the regulation of different isoforms of adenylyl cyclase.
Check Digit Verification of cas no
The CAS Registry Mumber 21215-62-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,2,1 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 21215-62:
(7*2)+(6*1)+(5*2)+(4*1)+(3*5)+(2*6)+(1*2)=63
63 % 10 = 3
So 21215-62-3 is a valid CAS Registry Number.
InChI:InChI=1/C151H228N40O45S3/c1-17-75(8)118(144(229)163-67-114(205)183-117(74(6)7)143(228)162-64-112(203)165-77(10)150(235)190-50-29-38-106(190)124(158)209)185-125(210)76(9)166-145(230)120(79(12)194)186-131(216)92(45-47-109(155)200)170-142(227)107-39-30-51-191(107)151(236)103(58-85-35-25-20-26-36-85)180-148(233)122(81(14)196)188-139(224)99(59-87-63-159-71-164-87)176-133(218)96(55-83-31-21-18-22-32-83)174-128(213)90(37-27-28-49-152)168-136(221)101(61-111(157)202)177-134(219)97(56-84-33-23-19-24-34-84)175-137(222)102(62-116(207)208)178-129(214)91(44-46-108(154)199)171-147(232)121(80(13)195)187-138(223)98(57-86-40-42-88(198)43-41-86)179-146(231)119(78(11)193)184-115(206)66-161-127(212)94(53-72(2)3)172-130(215)93(48-52-239-16)169-141(226)105(70-238)182-149(234)123(82(15)197)189-140(225)104(68-192)181-132(217)95(54-73(4)5)173-135(220)100(60-110(156)201)167-113(204)65-160-126(211)89(153)69-237/h18-26,31-36,40-43,63,71-82,89-107,117-123,192-198,237-238H,17,27-30,37-39,44-62,64-70,152-153H2,1-16H3,(H2,154,199)(H2,155,200
