212188-60-8

Basic information

• Product Name: (R)-3-(2-(hydroxymethyl)-2,3-dihydro-1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1-sulfonate
• Synonyms: (R)-3-(2-(hydroxymethyl)-2,3-dihydro-1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1-sulfonate;BAY 38-7271;KN 38-7271;O-1861 (R-form);BAY-38-7071;1-Butanesulfonic acid, 4,4,4-trifluoro-,3-[[(2R)-2,3-dihydro-2-(hydroxyMethyl)-1H-inden-4-yl]oxy]phenyl ester;4,4,4-Trifluoro-1-butanesulfonic acid 3-[[(2R)-2,3-dihydro-2-(hydroxymethyl)-1H-inden-4-yl]oxy]phenyl ester
• CAS NO: 212188-60-8
• Molecular Formula: C20H21F3O5S
• Molecular Weight: 430.4379496
• Product Categories: Pharmaceutical intermediate
• Mol File: 212188-60-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 527.206 °C at 760 mmHg
• Flash Point: 272.645 °C
• Appearance: /
• Density: 1.351 g/cm³
• PKA: 14.81±0.10(Predicted)
• CAS DataBase Reference: (R)-3-(2-(hydroxymethyl)-2,3-dihydro-1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1-sulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(2-(hydroxymethyl)-2,3-dihydro-1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1-sulfonate(212188-60-8)
• EPA Substance Registry System: (R)-3-(2-(hydroxymethyl)-2,3-dihydro-1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1-sulfonate(212188-60-8)

Safety Data

• Hazardous Substances Data: 212188-60-8(Hazardous Substances Data)

Usage

Description

(R)-3-(2-(hydroxymethyl)-2,3-dihydro-1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1-sulfonate, also known as BAY 38-7271 or KN 38-7271, is a chemical compound originally synthesized by chemist Wayne E. Kenney. It is a cannabinoid receptor agonist developed by Bayer AG, characterized by its analgesic and neuroprotective effects. (R)-3-(2-(hydroxymethyl)-2,3-dihydro-1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1-sulfonate exhibits full agonist activity with similar potency to CP 55,940 in animal studies and demonstrates high affinity for both CB1 and CB2 receptors.

Uses

Used in Scientific Research:
(R)-3-(2-(hydroxymethyl)-2,3-dihydro-1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1-sulfonate is used as a research tool for studying the effects of cannabinoid receptor agonists on various biological processes and their potential therapeutic applications.
Used in Pharmaceutical Development:
(R)-3-(2-(hydroxymethyl)-2,3-dihydro-1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1-sulfonate is used as a drug candidate for the treatment of traumatic brain injury. Its development has been licensed to KeyNeurotek Pharmaceuticals, and it was in Phase II trials in 2008, although its development appears to have stopped.
Used in Neurological Applications:
In the field of neurology, (R)-3-(2-(hydroxymethyl)-2,3-dihydro-1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1-sulfonate is used as a potential therapeutic agent for traumatic brain injury due to its analgesic and neuroprotective properties.
Used in Pain Management:
(R)-3-(2-(hydroxymethyl)-2,3-dihydro-1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1-sulfonate is used as an analgesic agent, targeting cannabinoid receptors to alleviate pain and potentially improve the management of various painful conditions.