21230-07-9 Usage
Description
Benzenesulfonamide, 4-methyl-N-(1-methylethyl)-, also known as N-Isopropyl-4-methylbenzenesulfonamide, is a chemical compound belonging to the class of sulfonamides. It is characterized by the presence of a benzene ring with a sulfonamide group attached to it, along with a methyl and an isopropyl substituent. Benzenesulfonamide, 4-methyl-N-(1-methylethyl)exhibits unique chemical properties and reactivity, making it a versatile building block in organic synthesis and a potential candidate for various applications.
Uses
Used in Organic Synthesis:
Benzenesulfonamide, 4-methyl-N-(1-methylethyl)-, is used as an intermediate in the synthesis of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, such as nucleophilic substitutions, electrophilic aromatic substitutions, and rearrangement reactions. This makes it a valuable component in the development of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Benzenesulfonamide, 4-methyl-N-(1-methylethyl)-, is used as a building block for the synthesis of various drug candidates. Its ability to form stable derivatives and participate in diverse chemical reactions makes it a promising candidate for the development of new drugs with improved therapeutic properties.
Used as Alkylating Reagents:
Benzenesulfonamide, 4-methyl-N-(1-methylethyl)-, is used as an alkylating reagent in the N-alkylation of sulfonamides using inactive ethers. This application is particularly relevant in the synthesis of various sulfonamide-based compounds, which have a wide range of applications in the pharmaceutical and chemical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 21230-07-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,2,3 and 0 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 21230-07:
(7*2)+(6*1)+(5*2)+(4*3)+(3*0)+(2*0)+(1*7)=49
49 % 10 = 9
So 21230-07-9 is a valid CAS Registry Number.
21230-07-9Relevant articles and documents
Intramolecular NC rearrangements involving sulfonamide protecting groups
Saidykhan, Amie,Bowen, Richard D.,Gallagher, Richard T.,Martin, William H.C.
, p. 66 - 68 (2015)
The reaction of amine derivatives orthogonally protected with an aryl sulfonamide and a carbamate, via a base-mediated nitrogen to carbon rearrangement is reported. This noteworthy isomerisation has implications for the use of sulfonamide protecting group
Au(I)-Catalyzed Oxidative Functionalization of Yndiamides
Tong, Zixuan,Garry, Olivia L.,Smith, Philip J.,Jiang, Yubo,Mansfield, Steven J.,Anderson, Edward A.
supporting information, p. 4888 - 4892 (2021/06/28)
Yndiamides, underexplored cousins of ynamides, offer rich synthetic potential as doubly nitrogenated two carbon building blocks. Here we report a gold-catalyzed oxidative functionalization of yndiamides to access unnatural amino acid derivatives, using a wide range of nucleophiles as a source of the amino acid side chain. The transformation proceeds under mild conditions, is highly functional group tolerant, and displays excellent regioselectivity through subtle steric differentiation of the yndiamide nitrogen atom substituents.
Structurally Diverse Synthesis of Five-, Six-, and Seven-Membered Benzosultams through Electrochemical Cyclization
Liu, Aiyun,Guo, Tiantian,Zhang, Shuangshuang,Yang, Han,Zhang, Qi,Chai, Yonghai,Zhang, Shengyong
supporting information, p. 6326 - 6331 (2021/08/23)
We have developed a metal- and oxidant-free approach to structurally diverse synthesis of benzosultams from aryl sulfonamides through an electrochemical cyclization. Upon variation of the ortho substituent on aryl sulfonamides, five-, six-, and seven-memb
