21260-50-4

Basic information

• Product Name: N-butyl-N'-(4'-nitrophenyl)urea
• Synonyms: N-butyl-N'-(4'-nitrophenyl)urea
• CAS NO: 21260-50-4
• Molecular Weight: 237.258
• Mol File: 21260-50-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-butyl-N'-(4'-nitrophenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: N-butyl-N'-(4'-nitrophenyl)urea(21260-50-4)
• EPA Substance Registry System: N-butyl-N'-(4'-nitrophenyl)urea(21260-50-4)

Safety Data

• Hazardous Substances Data: 21260-50-4(Hazardous Substances Data)

Upstream product

• 53821-12-8 benzyl 4-(nitro)phenylcarbamate 
• 109-73-9 N-butylamine 
• 100-01-6 4-nitro-aniline 
• 111-36-4 n-butyl isocyanide 
• 100-28-7 4-Nitrophenyl isocyanate 
• 51-58-1 N-carbamimidoyl-N'-(4-nitro-phenyl)-urea; hydrochloride 

Downstream Products

• 587-90-6 bis-N,N'-(4-nitrophenyl)urea 

Relevant articles and documents

‘Frustrated’ hydrogen-bonded self-associated systems as templates towards DNA incorporated nanostructure formation

Herein, we present the synthesis of a thymine nucleobase-appended ‘frustrated’ monomer, which exhibits self-association in DMSO solutions through the formation of hydrogen bonds. This self-association process has been explored in both competitive DMSO solutions and the solid state, using a combination of NMR and single crystal X-ray diffraction techniques. The self-associative equilibria within the solution state are balanced in such a way that the hydrogen bond donating and accepting thymine residue present within the monomeric structure is free to coordinate further guest species such as the complimentary DNA base adenine. The adenine simulants, 2-aminopyridine and 2,6-diaminopyridine have been used to explore the potential of these self-associated structures towards the coordination of complimentary DNA base pairs.

Antiproliferative effects of novel urea derivatives against human prostate and lung cancer cells; And their inhibition of β-glucuronidase activity

Twenty-one novel urea derivatives were synthesized and their structures characterized by mass, NMR, IR, and UV spectroscopy. These compounds were evaluated for their antiproliferative profile against human PC-3 (prostate) and NCI-H460 (lung) cancer cell lines. Among them, compound 21 N-(3-nitrophenyl)- N′-(1-phenylethyl)urea was found to be active against both PC-3 (IC 50 ± SEM: 20.13 ± 0.91 μM) and NCI-H460 (GI 50: 22 ± 2.6 μM) cell lines; hence has the potential to be further studied as anticancer agent. These compounds were also investigated for their ability to inhibit urease, β-glucuronidase, and phosphodiesterase enzymes. N-(2,6-Dimethylphenyl)-N′-(4′-nitrophenyl)urea (1) demonstrated 90 % inhibition of β-glucuronidase enzyme (IC50 ± SEM: 3.38 ± 0.043 μM).

Substituted urea derivatives: A potent class of antidepressant agents

A series of fourteen (14) N-nitrophenyl-N'-(alkyl/aryl)urea and symmetrical 1,3-disubstituted urea derivatives were synthesized and evaluated for their antidepressant activity in mice. Among them, N-(4-nitrophenyl)-N'-(1'- phenylethyl)urea (1), demonstrat