212650-43-6

Basic information

• Product Name: MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER
• Synonyms: 4-N-BOC-3-MORPHOLINECARBOXYLIC ACID;4-(TERT-BUTOXYCARBONYL)MORPHOLINE-3-CARBOXYLIC ACID;MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER;(S)-Morpholine-3,4-dicarboxylic acid 4-tert-butyl;Morpholine-3,4-dicarboxylic acid 4-tert-butyl;N-Boc-Morpholine-2-carboxylic acid;N-Boc-morpholine-3-carboxylic acid;4-Boc-3-morpholinecarboxylic acid
• CAS NO: 212650-43-6
• Molecular Formula: C₁₀H₁₇NO₅
• Molecular Weight: 231.25
• Product Categories: pharmacetical
• Mol File: 212650-43-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 369℃
• Flash Point: 177℃
• Appearance: /
• Density: 1.230
• Vapor Pressure: 1.8E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 3.53±0.20(Predicted)
• CAS DataBase Reference: MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER(212650-43-6)
• EPA Substance Registry System: MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER(212650-43-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-51-36
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 212650-43-6(Hazardous Substances Data)

Usage

General Description

Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups. Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester is rarely natural and primarily synthesized in laboratories for its potential uses in the chemical industry. Its detailed chemical composition and properties are not widely researched; however, like other esters, it's expected to have characteristics including potential reactivity with water and various acids and stability under normal temperatures and pressures. It could be harmful if ingested or gotten in eyes, or if it comes into contact with the skin. Detailed toxicity data is lacking.

InChI:InChI=1/C10H17NO5/c1-10(2,3)16-9(14)11-4-5-15-6-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/p-1/t7-/m0/s1

Upstream product

• 77873-76-8 morpholine-3-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 473923-56-7 tert-Butyl 3-(hydroxymethyl)-4-morpholinecarboxylate 
• 126264-49-1 methyl 3-morpholine-carboxylate 
• 212650-45-8 morpholine-3,4-dicarboxylic acid 4-tert-butyl ester 3-methyl ester 
• 66937-99-3 morpholine-3-carboxylic acid hydrochloride 

Downstream Products

• 518047-39-7 tert-butyl 3-(aminocarbonyl)morpholine 4-carboxylate 
• 518047-40-0 tert-butyl 3-cyanomorpholine-4-carboxylate 
• 518058-62-3 tert-butyl 3-[amino(hydroxyimino)methyl]morpholine-4-carboxylate 
• 519030-38-7 N-(4-fluorobenzyl)-5,6-dihydroxy-2-(morpholin-3-yl)pyrimidine-4-carboxamide 
• 212650-45-8 morpholine-3,4-dicarboxylic acid 4-tert-butyl ester 3-methyl ester 
• 833474-06-9 tert-butyl 3-formylmorpholine-4-carboxylate 
• 473923-56-7 tert-Butyl 3-(hydroxymethyl)-4-morpholinecarboxylate 
• 1020839-67-1 C₂₉H₃₂N₄O₅ 
• 1020840-10-1 3(R,S)-{4-[3-(5-chloro-2-hydroxy-phenyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-4-ylethynyl]-phenylcarbamoyl}-morpholine-4-carboxylic acid tert-butyl ester 
• 848488-74-4 morpholine-3-carboxamide 
• 1160829-43-5 3-{4-[3-(1-methyl-1H-benzoimidazol-2-yl)-phenyl]-piperazine-1-carbonyl}-morpholine-4-carboxylic acid tert-butyl ester 
• 1207428-21-4 C₈H₁₁N*C₁₀H₁₇NO₅ 
• 1240518-77-7 1,1-dimethylethyl 3-{[({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-hydroxy-1H-indazol-1-yl)methyl]phenyl}methyl)amino]carbonyl}-4-morpholinecarboxylate 
• 141108-65-8 octahydropyrazino[2,1-c][1,4]oxazine 

Relevant articles and documents

Preparation method N-t-butyloxycarboryl morpholine-3-carboxylic acid

The invention provides a preparation method of N-t-butyloxycarboryl morpholine-3-carboxylic acid. According to the preparation method, 1,2-epoxypropane is taken as a raw material, ring-opening reaction, cyclization reaction, hydrolysis reaction, and nitrogen protection reaction are carried out successively so as to obtain N-t-butyloxycarboryl morpholine-3-carboxylic acid, wherein the ring-openingreaction is carried out under catalytic effect of transition metal Lewis acid. Reaction conditions are mild; operation is simple; no severely toxic side product is generated; the reaction yield of each step is 80% or higher; the reaction yield of a part reaction steps is 90% or higher; the yield is high; the preparation method is beneficial for large scale production, and is high in market value.

Synthesis of 3-oxadiazolyl/triazolyl morpholines: Novel scaffolds for drug discovery

Synthesis of isomeric 3-oxadiazolyl/triazolyl morpholines was performed based on a common intermediate on the gram scale. The target compounds were designed as novel scaffolds for the medicinal chemistry. The key reaction was an electrochemical CH-oxidati

SUBSTITUTED MORPHOLINES AS MODULATORS FOR THE CALCIUM SENSING RECEPTOR

Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors of Formula (I).