21279-64-1

Basic information

• Product Name: 5-chloropyrazine-2-carboxamide
• Synonyms: 5-chloropyrazine-2-carboxamide;5-Chloro-2-pyrazinecarboxamide;EOS-61239
• CAS NO: 21279-64-1
• Molecular Formula: C₅H₄ClN₃O
• Molecular Weight: 157.56
• EINECS: 1312995-182-4
• Mol File: 21279-64-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 331.3 °C at 760 mmHg
• Flash Point: 154.2 °C
• Appearance: /
• Density: 1.479 g/cm³
• Vapor Pressure: 0.000157mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-chloropyrazine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloropyrazine-2-carboxamide(21279-64-1)
• EPA Substance Registry System: 5-chloropyrazine-2-carboxamide(21279-64-1)

Safety Data

• Hazardous Substances Data: 21279-64-1(Hazardous Substances Data)

Usage

General Description

5-Chloropyrazine-2-carboxamide is a chemical compound with the molecular formula C5H3ClN4O. It is a derivative of pyrazine and is used in the synthesis of pharmaceuticals and agrochemicals. 5-chloropyrazine-2-carboxamide is known for its potential as an inhibitor of the enzyme ribonucleotide reductase, which is involved in DNA synthesis. It also has applications in the field of organic chemistry, where it can be used as a building block for the creation of more complex molecules. Additionally, 5-chloropyrazine-2-carboxamide has been studied for its potential antimicrobial and antifungal properties, making it a versatile and important chemical in the pharmaceutical and agricultural industries.

InChI:InChI=1/C5H4ClN3O/c6-4-2-8-3(1-9-4)5(7)10/h1-2H,(H2,7,10)

Upstream product

• 14508-49-7 2-chloropyrazin 
• 77287-34-4 formamide 
• 36070-75-4 5-chloro-2-pyrazinecarbonitrile 
• 88625-23-4 5-chloropyrazine-2-carbonyl chloride 
• 98-96-4 pyrazinamide 
• 768-36-5 2-pyrazinecarboxamide-4-oxide 
• 33332-25-1 methyl 5-chloropyrazine-2-carboxylate 
• 34604-60-9 5-hydroxypyrazinoic acid 
• 36070-80-1 5-chloropyrazinoic acid 

Downstream Products

• 74416-17-4 5-Chloro-4-oxy-pyrazine-2-carboxylic acid amide 
• 735221-62-2 Pyrazinamide-5-sulfonic acid 
• 36070-75-4 5-chloro-2-pyrazinecarbonitrile 
• 1352012-75-9 tert-butyl 4-[2-(5-carbamoylpyrazin-2-ylamino)ethyl]piperidine-1-carboxylate 
• 1352012-47-5 2,2,2-trifluoro-1-(trifluoromethyl)ethyl 4-[2-(5-carbamoylpyrazin-2-ylamino)ethyl]piperidine-1-carboxylate 
• 89323-09-1 5-aminopyrazine-2-carboxamide 
• 1537901-91-9 5-(methylamino)pyrazine-2-carboxamide 
• 1537901-92-0 5-(ethylamino)pyrazine-2-carboxamide 
• 1537901-93-1 5-(propylamino)pyrazine-2-carboxamide 
• 1537901-94-2 5-(butylamino)pyrazine-2-carboxamide 
• 1537901-95-3 5-(pentylamino)pyrazine-2-carboxamide 
• 1537901-96-4 5-(hexylamino)pyrazine-2-carboxamide 
• 1537901-97-5 5-(heptylamino)pyrazine-2-carboxamide 
• 1537901-98-6 5-(octylamino)pyrazine-2-carboxamide 

Relevant articles and documents

Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

A series of 6-hetaryloxy benzoxaborole compounds was designed and synthesized for a structure-activity relationship (SAR) investigation to assess the changes in antimalarial activity which result from 6-aryloxy structural variation, substituent modification on the pyrazine ring, and optimization of the side chain ester group. This SAR study discovered highly potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles (9, 27-34) with IC50s = 0.2-22 nM against cultured Plasmodium falciparum W2 and 3D7 strains. Compound 9 also demonstrated excellent in vivo efficacy against P. berghei in infected mice (ED90 = 7.0 mg/kg).

BENZENE OR THIOPHENE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR

The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.

In vitro antimycobacterial activity of 5-chloropyrazinamide

5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis, Mycobacterium bovis, and several nontuberculous mycobacteria by a broth dilution method. 5- Chloropyrazinamide was more active than pyrazinamide against all organisms tested. It is likely that this agent has a different mechanism of action than pyrazinamide.