212909-78-9Relevant articles and documents
Zr-catalyzed kinetic resolution of allylic ethers and mo-catalyzed chromene formation in synthesis. Enantioselective total synthesis of the antihypertensive agent (S,R,R,R)-nebivolol
Johannes, Charles W.,Visser, Michael S.,Weatherhead, Gabriel S.,Hoveyda, Amir H.
, p. 8340 - 8347 (2007/10/03)
The first enantioselective total synthesis of the antihypertensive agent (S,R,R,R)-nebivolol (3) is described. The synthesis includes the efficient (EBTHI)Zr-catalyzed kinetic resolutions of cycloheptenyl styrenyl ethers 8 and 16, which are subsequently t