212968-67-7

Basic information

• Product Name: Benzenemethanamine, 4-ethyl-a-methyl-, (aS)-
• Synonyms: Benzenemethanamine, 4-ethyl-a-methyl-, (aS)-;Benzenemethanamine, 4-ethyl-α-methyl-, (αS)-;Benzenemethanamine, 4-ethyl-.alpha.-methyl-, (.alpha.S)-;(S)-1-(4-ETHYLPHENYL)ETHANAMINE-HCl;(1S)-1-(4-ETHYLPHENYL)ETHAN-1-AMINE HYDROCHLORIDE;(S)-1-(4-ethylphenyl)ethan-1-amine
• CAS NO: 212968-67-7
• Molecular Formula: C10H15N
• Molecular Weight: 149.236
• Product Categories: API intermediates
• Mol File: 212968-67-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 229.7°C at 760 mmHg
• Flash Point: 97.5°C
• Appearance: /
• Density: 0.935g/cm³
• Vapor Pressure: 0.0687mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: Benzenemethanamine, 4-ethyl-a-methyl-, (aS)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, 4-ethyl-a-methyl-, (aS)-(212968-67-7)
• EPA Substance Registry System: Benzenemethanamine, 4-ethyl-a-methyl-, (aS)-(212968-67-7)

Safety Data

• Hazardous Substances Data: 212968-67-7(Hazardous Substances Data)

Usage

General Description

Benzenemethanamine, 4-ethyl-a-methyl-, (aS)- is a chemical compound with the chemical formula C10H15N. It is also known as (S)-N-Ethyl-1-(4-methylphenyl)propan-2-amine, and it is an enantiomer of methamphetamine. Benzenemethanamine, 4-ethyl-a-methyl-, (aS)- is a psychoactive substance and is classified as a Schedule II controlled substance due to its potential for abuse and addiction. It has stimulant effects on the central nervous system and is often used recreationally for its euphoric and energizing effects. Its use is strictly regulated and illegal without a prescription due to its potential for abuse and addiction.

InChI:InChI=1/C10H15N/c1-3-9-4-6-10(7-5-9)8(2)11/h4-8H,3,11H2,1-2H3/t8-/m0/s1

Upstream product

• 937-30-4 4-ethylacetophenone 
• 147116-33-4 1-(4-ethylphenyl)ethylamine 

Downstream Products

• 1420534-83-3 C₁₂H₁₇NO 

Relevant articles and documents

Resolution of 1-arylalkylamines with 6-(1,2:3,4-di-O-isopropylidene- α-D-galactopyranosyl)hydrogen phthalate

The resolving ability of a new acidic resolving agent, the hydrogen phthalate of 1,2:3,4-di-O-isopropylidene-α-D-galactopyranose 1, against various 1-arylalkylamines 2a-k is described. Treatment of 1 with amines 2a-f to obtain diastereomeric salts 1·(S)2a-f in 2-propanol allowing the corresponding (S)-amines 2a-f to be recovered in good yield and 61-89% ee. Recrystallization in dichloromethane/hexane, and regeneration gave the amines in enhanced enantiomeric purity (>98% ee). 1 resolved 1-phenylpropylamine 2f in high enantiomeric purity (99% ee) than 1-phenylethylamine 2g (11% ee) and o- and m-methoxy 2h-i, o-chloro-2j and p-fluoro-2k substituted 1-arylamines (11-19% ee). A possible chiral recognition mechanism based on the ability of 1 to exist in two conformations is described.

Ultra-small cobalt nanoparticles from molecularly-defined Co-salen complexes for catalytic synthesis of amines

We report the synthesis of in situ generated cobalt nanoparticles from molecularly defined complexes as efficient and selective catalysts for reductive amination reactions. In the presence of ammonia and hydrogen, cobalt-salen complexes such as cobalt(ii)-N,N′-bis(salicylidene)-1,2-phenylenediamine produce ultra-small (2-4 nm) cobalt-nanoparticles embedded in a carbon-nitrogen framework. The resulting materials constitute stable, reusable and magnetically separable catalysts, which enable the synthesis of linear and branched benzylic, heterocyclic and aliphatic primary amines from carbonyl compounds and ammonia. The isolated nanoparticles also represent excellent catalysts for the synthesis of primary, secondary as well as tertiary amines including biologically relevant N-methyl amines.

Rh(III)-Catalyzed Coupling of N-Chloroimines with α-Diazo-α-phosphonoacetates for the Synthesis of 2 H-Isoindoles

We report herein the first use of N-chloroimines as effective synthons for directed C-H functionalization. Rh(III)-catalyzed coupling of N-chloroimines with α-diazo-α-phosphonoacetates allows for efficient dechlorinative/dephosphonative access to 2H-isoindoles. Further deesterification under Ni(II) catalysis enables the complete elimination of reactivity-assisting groups and full exposure of reactivity of C3 and N2 ring atoms for attaching structurally distinct appendages.