21304-53-0Relevant articles and documents
Radical C-H Arylation of Oxazoles with Aryl Iodides: Dppf as an Electron-Transfer Mediator for Cs2CO3
Guo, Zhengwei,Li, Man,Mou, Xue-Qing,He, Gang,Xue, Xiao-Song,Chen, Gong
supporting information, p. 1684 - 1687 (2018/03/23)
A radical C-H arylation reaction of oxazoles with (hetero)aryl iodides using Cs2CO3 as base/electron donor and 1,1′-bis(diphenylphosphino) ferrocene (dppf) as a catalytic SET mediator is reported. The overall reaction likely follows the general base-promoted homolytic aromatic substitution mechanism through a radical-chain pathway. DFT calculations suggest that dppf forms a complex with CsCO3-, enhancing its SET reducing ability to generate an aryl radical from ArI.
Metal-free dual sp3 C-H functionalization: I2- promoted domino oxidative cyclization to construct 2,5-disubstituted oxazoles
Gao, Qing-He,Fei, Zhuan,Zhu, Yan-Ping,Lian, Mi,Jia, Feng-Cheng,Liu, Mei-Cai,She, Neng-Fang,Wu, An-Xin
, p. 22 - 28 (2013/01/15)
An I2-promoted sp3 C-H functionalization has been developed for the synthesis of 2,5-disubstituted oxazoles from easily available methyl ketones and benzylamines without any metal and peroxide catalyst. This domino oxidative cyclization process involves the cleavage of C-H bond and the formation of C-N, C-O bonds.
Combinatorial discovery of novel fluorescent dyes based on Dapoxyl
Zhu, Qing,Yoon, Hai-Shin,Parikh, Puja B.,Chang, Young-Tae,Yao, Shao Q.
, p. 5083 - 5086 (2007/10/03)
We have developed a combinatorial method for the fast and effective synthesis of a library based on a known fluorescent dye, Dapoxyl using parallel solution-phase chemistry. By screening the 140 new compounds using fluorescence-based assays, we identified three new fluorescent dyes with novel properties.
