213262-06-7Relevant articles and documents
A new efficient synthesis of 5-aryloxazoles from arylidene diacetates and application to the preparation of BMS-337197, a novel IMPDH inhibitor
Chen, Bang-Chi,Bednarz, Mark S.,Zhang, Huiping,Zhao, Rulin,Murali,Balu Balasubramanian, Dhar,Barrish, Joel C.
, p. 167 - 173 (2007/10/03)
A new method for the synthesis of 5-aryloxazoles is described. Treatment of arylidene diacetates with one equivalent of TosMIC reagent in the presence of excess of potassium carbonate in methanol afforded 5-aryloxazoles in "one-pot" in 90-94%. Heteroaryli
USE OF COMPOUNDS HAVING AN AMINE NUCLEUS IN MANUFACTURE OF A MEDICAMENT USEFUL FOR TREATING FACTOR VIIA-ASSOCIATED CONDITIONS
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Page 42-43, (2008/06/13)
Use of at least one compound having the formula (I), or a pharmaceutically-acceptable salt, hydrate or prodrug thereof, in the manufacture of a medicament useful for treating conditions associated with the activity of Factor VIIa is described.
A survey of cyclic replacements for the central diamide moiety of inhibitors of inosine monophosphate dehydrogenase
Dhar,Liu, Chunjian,Pitts, William J.,Guo, Junquing,Watterson, Scott H.,Gu, Henry,Fleener, Catherine A.,Rouleau, Katherine,Sherbina,Barrish, Joel C.,Hollenbaugh, Diane,Iwanowicz, Edwin J.
, p. 3125 - 3128 (2007/10/03)
A series of heterocyclic replacements for the central diamide moiety of 1, a potent small molecule inhibitor of inosine monophosphate dehydrogenase (IMPDH) were explored. The synthesis and the structure-activity relationships (SARs), derived from in vitro
