21352-09-0 Usage
Description
2-Chloro-6-methylacetanilin, with the chemical formula C8H10ClNO and CAS number 21352-09-0, is an organic compound that belongs to the class of acetanilides. It features a chlorine atom at the 2nd position and a methyl group at the 6th position on the benzene ring, with an amide functional group attached to the nitrogen atom. 2-CHLORO-6-METHYLACETANILINE is known for its reactivity in electrophilic substitution reactions, making it a valuable intermediate in the synthesis of various organic compounds.
Uses
Used in Organic Synthesis:
2-Chloro-6-methylacetanilin is used as a reagent for electrophilic substitution reactions of 2'',4''and 2'',6''-dihaloacetanilides. Its unique structure allows for selective substitution at specific positions on the benzene ring, enabling the synthesis of a wide range of organic compounds with diverse applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-chloro-6-methylacetanilin serves as a key intermediate in the synthesis of various drug molecules. Its reactivity in electrophilic substitution reactions allows for the introduction of different functional groups, which can enhance the pharmacological properties of the resulting drug candidates.
Used in Agrochemical Industry:
2-Chloro-6-methylacetanilin is also utilized in the agrochemical industry for the synthesis of various pesticides and herbicides. Its ability to undergo electrophilic substitution reactions enables the development of new and more effective compounds for controlling pests and weeds in agricultural settings.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 2-chloro-6-methylacetanilin is employed as a starting material for the synthesis of various dyes and pigments. Its reactivity in electrophilic substitution reactions allows for the creation of a wide range of colored compounds with different shades and properties, suitable for various applications such as textiles, plastics, and printing inks.
Used in Research and Development:
2-Chloro-6-methylacetanilin is a valuable compound for research and development purposes, particularly in the field of organic chemistry. Its reactivity in electrophilic substitution reactions makes it an ideal candidate for studying reaction mechanisms, exploring new synthetic routes, and developing innovative applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 21352-09-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,3,5 and 2 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 21352-09:
(7*2)+(6*1)+(5*3)+(4*5)+(3*2)+(2*0)+(1*9)=70
70 % 10 = 0
So 21352-09-0 is a valid CAS Registry Number.
21352-09-0Relevant articles and documents
Synthesis method of key raw material 2-chloro-6-methylaniline of dasatinib
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Paragraph 0016; 0033; 0036; 0038; 0041, (2021/04/21)
The invention discloses a synthetic method of a key raw material 2-chloro-6-methylaniline of dasatinib. The method comprises the following steps: firstly, protecting a 1-site amino group of 2-nitro-6-methylaniline, then reducing a 2-site nitro group of 2-nitro-6-methylaniline into an amino group, then carrying out diazotization reaction, carrying out chlorine substitution on the 2-site amino group by using cuprous chloride, and finally, carrying out acidolysis to remove a 1-site amino protecting group to obtain 2-chlorine-6-methylaniline. The method has the advantages of cheap and easily available raw materials, easily controllable reaction, simple operation steps, simple post-treatment, recyclable solvents, small pollution, and suitableness for large-scale production of generative enterprises.
Imidazolium Salt Catalyzed para -Selective Halogenation of Electron-Rich Arenes
Chen, Jie,Xiong, Xiaoyu,Chen, Zenghua,Huang, Jianhui
supporting information, p. 2831 - 2834 (2015/12/18)
A highly para-selective halogenation of arenes bearing coordinating groups in the presence of a dimidazolium salt as a catalyst is reported. A series of electron-rich p-haloarenes were prepared in good yields and good to excellent selectivities. We also propose a plausible mechanism for the catalytic reaction.
Novel Reactions: Part I - Facile Synthesis of Substituted ortho-Chloranilines from Nitrobenzene Derivatives
Ayyangar, N. R.,Kalkote, U. R.,Nikrad, P. V.
, p. 872 - 877 (2007/10/02)
N-Substituted benzo and acetohydroxamic acids (5), prepared from N-arylhydroxylamines and benzoyl or acetyl chloride, react readily with thionyl chloride at low temperature to give ortho-chloroanilide derivatives (6) in good yield.The latter (6) on hydrolysis give ortho-chloroanilines (10).Since the N-arylhydroxylamines are obtained from nitroarenes by partial reduction, the overall reaction amounts to the preparation of 10 from nitroarenes.
