213771-32-5

Basic information

• Product Name: 5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester
• Synonyms: 5-Bromo-3-methylpicolinic acid methyl ester;5-BroMo-3-Methylpyridine-2-Carboxylic Acid Methyl;Methyl 5-bromo-3-methylpicolinate, 5-Bromo-2-(methoxycarbonyl)-3-methylpyridine;2-Pyridinecarboxylic acid, 5-bromo-3-methyl-, methyl ester;Methyl 5-Bromo-3-methylpicolinate;Methyl 5-bromo-3-methyl-pyridine-2-carboxylate
• CAS NO: 213771-32-5
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.05862
• Product Categories: Heterocycle-Pyridine series
• Mol File: 213771-32-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 302.2 °C at 760 mmHg
• Flash Point: 136.6 °C
• Appearance: /
• Density: 1.503
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: Room temperature.
• PKA: -0.17±0.10(Predicted)
• CAS DataBase Reference: 5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester(213771-32-5)
• EPA Substance Registry System: 5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester(213771-32-5)

Safety Data

• Hazardous Substances Data: 213771-32-5(Hazardous Substances Data)

Usage

General Description

5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester is a chemical compound with the molecular formula C8H8BrNO2. It is a derivative of pyridine, a heterocyclic organic compound. 5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It has also been studied for its potential use in the development of new therapeutic agents. The ester group in the molecule makes it suitable for use in organic synthesis, and its bromine substituent provides unique reactivity that can be exploited in chemical transformations. Overall, 5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester is a versatile chemical compound with potential applications in drug development and organic synthesis.

InChI:InChI=1/C8H8BrNO2/c1-5-3-6(9)4-10-7(5)8(11)12-2/h3-4H,1-2H3

Upstream product

• 67-56-1 methanol 
• 3430-18-0 2,5-dibromo-3-methylpyridine 
• 201230-82-2 carbon monoxide 
• 156072-86-5 5-bromo-3-methylpyridine-2-carbonitrile 
• 886365-43-1 5-bromo-3-methylpyridine-2-carboxylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 1048678-21-2 5-bromo-3-bromomethylpyridine-2-carboxylic acid methyl ester 
• 1202250-75-6 3-methyl-5-(3-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid methyl ester 
• 1335299-16-5 5-Bromo-3-methyl-pyridine-2-carboxylic acid (2-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-amide 
• 1254318-86-9 (S)-4-amino-N-(1-cyano-2-(4-(6-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)phenyl)ethyl)tetrahydro-2H-pyran-4-carboxamide 
• 1352152-94-3 (S)-tert-butyl 1-(1-amino-3-(4-(6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)cyclohexylcarbamate 
• 1352152-95-4 (S)-tert-butyl 1-(1-cyano-2-(4-(6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)phenyl)ethylcarbamoyl)cyclohexylcarbamate 
• 1352152-92-1 (S)-1-amino-N-(1-cyano-2-(4-(6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)phenyl)ethyl)cyclohexanecarboxamide 
• 1352152-15-8 (S)-tert-butyl 1-(1-amino-3-(4-(6-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)cyclohexylcarbamate 
• 1352152-16-9 (S)-tert-butyl 1-(1-cyano-2-(4-(6-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)phenyl)ethylcarbamoyl)cyclohexylcarbamate 
• 1346809-61-7 3-bromo-5H-pyrrolo[3,4-b]pyridin-7(6H)-one 
• 1352152-27-2 (S)-tert-butyl 1-(1-amino-1-oxo-3-(4-(7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)phenyl)propan-2-ylcarbamoyl)cyclohexylcarbamate 
• 1352152-28-3 (S)-tert-butyl 1-(1-cyano-2-(4-(7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)phenyl)ethylcarbamoyl)cyclohexylcarbamate 
• 1352152-26-1 (S)-1-amino-N-(1-cyano-2-(4-(7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)phenyl)ethyl)cyclohexanecarboxamide 
• 1430058-57-3 2-[(2S)-2-(3-bromo-7-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-3-(3-fluorophenyl)propyl]-1H-isoindole-1,3(2H)-dione 

Relevant articles and documents

Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor

Structure-based optimization of a set of aryl urea RAF inhibitors has led to the identification of Type II pan-RAF inhibitor GNE-9815 (7), which features a unique pyrido[2,3-d]pyridazin-8(7H)-one hinge-binding motif. With minimal polar hinge contacts, the pyridopyridazinone hinge binder moiety affords exquisite kinase selectivity in a lipophilic efficient manner. The improved physicochemical properties of GNE-9815 provided a path for oral dosing without enabling formulations. In vivo evaluation of GNE-9815 in combination with the MEK inhibitor cobimetinib demonstrated synergistic MAPK pathway modulation in an HCT116 xenograft mouse model. To the best of our knowledge, GNE-9815 is among the most highly kinase-selective RAF inhibitors reported to date.

INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS

The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

2-(PYRIDIN-3-YL)-PYRIMIDINE DERIVATIVES AS RET INHIBITORS

Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.