21397-08-0

Basic information

• Product Name: 2-Chloro-3-fluoroaniline
• Synonyms: BUTTPARK 44\01-95;2-CHLORO-3-FLUOROANILINE;2-Chloro-3-fluoroaniline 98%;2-Chloro-3-fluoroaniline98%;(2-chloro-3-fluoro-phenyl)amine;2-Chloro-3-fluoroaniline, 95+%
• CAS NO: 21397-08-0
• Molecular Formula: C₆H₅ClFN
• Molecular Weight: 145.56
• EINECS: 244-366-1
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Fluorobenzene;Aniline;API intermediates;Benzenes
• Mol File: 21397-08-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 210.3 °C at 760 mmHg
• Flash Point: 81 °C
• Appearance: /
• Density: 1.349 g/cm³
• Vapor Pressure: 2.99E-05mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1?+-.0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-3-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-fluoroaniline(21397-08-0)
• EPA Substance Registry System: 2-Chloro-3-fluoroaniline(21397-08-0)

Safety Data

• Hazard Codes: Xi,T
• Statements: 23/24/25
• Safety Statements: 36/37/39-45
• Hazardous Substances Data: 21397-08-0(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-fluoroaniline is a chemical compound with the molecular formula C6H5ClFN. It is a member of the aniline family, which is characterized by a phenyl ring connected to an amino group. This particular compound has a chlorine atom attached to the second carbon of the phenyl ring and a fluorine atom attached to the third carbon. It is used in the production of pharmaceuticals, dyes, and agrochemicals. 2-Chloro-3-fluoroaniline is known to be toxic and can cause skin and eye irritation, as well as respiratory issues if inhaled. It is important to handle and store this chemical with proper precautions to prevent harmful exposure.

InChI:InChI=1/C6H5BrFNO2S/c7-4-1-2-6(5(8)3-4)12(9,10)11/h1-3H,(H2,9,10,11)

Upstream product

• 21397-07-9 2-chloro-3-fluoro-nitrobenzene 
• 602-03-9 2,3-dinitroaniline 
• 102940-86-3 3-chloro-3-fluorobenzoic acid 
• 59255-94-6 2-bromo-3-fluoronitrobenzene 
• 7772-99-8 stannous chloride 
• 95-51-2 o-chloroaniline 
• 863870-86-4 2-chloro-3-fluorophenol 
• 863870-76-2 O-2-chloro-3-fluorophenyl N,N-diethylcarbamate 
• 1287791-65-4 2-(2-chloro-3-fluorophenoxy)-2-methylpropanamide 
• 1287791-75-6 N-(2-chloro-3-fluorophenyl)-2-hydroxy-2-methylpropanamide 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 205187-05-9 3-fluorophenyl N,N-diethyl-O-carbamate 

Downstream Products

• 947159-64-0 C₁₄H₁₀Cl₂FN₃O₃S 
• 880652-49-3 C₆H₄ClFIN 
• 364363-52-0 2-chloro-1-fluoro-3-isothiocyanatobenzene 
• 276702-09-1 N-[4-chloro-2-hydroxy-3-(aminosulfonyl)phenyl]-N'(2-chloro-3-fluorophenyl)-urea 
• 1070892-66-8 N-(3-fluoro-2-chloro-phenyl)formamide 
• 1160484-42-3 1-(2-chloro,3-fluorophenyl)-1H-1,2,3,4-tetrazole 
• 1138036-54-0 (2-chloro-3-fluorophenyl)hydrazine hydrochloride 
• 1263377-46-3 N-(2-chloro-3-fluorophenyl)thiourea 
• 1383453-29-9 C₁₄H₁₀ClFN₂O₄ 
• 1383453-75-5 C₁₈H₁₂ClFN₂O₅ 
• 1383453-80-2 C₁₇H₁₀ClFN₂O₅ 
• 1383452-70-7 C₂₂H₂₂ClFN₄O₄ 
• 1383452-75-2 C₂₁H₂₂ClFN₄O₃ 
• 1383453-38-0 C₁₅H₁₂ClFN₂O₄ 

Relevant articles and documents

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

Hydroxy diphenyl urea sulfonamides as IL-8 receptor antagonists

Novell IL-8 compounds and methods of using them are provided.

4 AND 5-Halo substituted 2-indanamine compounds

2-Indanamine compounds having 4 and 5-halo substituents are inhibitors of phenylethanolamine N-methyltransferase.