2142-76-9

Basic information

• Product Name: 2,6-DIMETHYLACETOPHENONE
• Synonyms: 2,6-DIMETHYLACETOPHENONE;Ethanone, 1-(2,6-dimethylphenyl)-;1-(2,6-Dimethyl-phenyl)-ethanone
• CAS NO: 2142-76-9
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.2
• EINECS: 218-400-0
• Product Categories: Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 2142-76-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 24℃ (ethanol )
• Boiling Point: 110-112 23mm
• Flash Point: 85.6 °C
• Appearance: /
• Density: 0.965 g/cm³
• Refractive Index: 1.5222 (589.3 nm 20℃)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,6-DIMETHYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIMETHYLACETOPHENONE(2142-76-9)
• EPA Substance Registry System: 2,6-DIMETHYLACETOPHENONE(2142-76-9)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 2142-76-9(Hazardous Substances Data)

Usage

General Description

2,6-Dimethylacetophenone is a chemical compound with the molecular formula C10H12O. It is a colorless to pale yellow liquid with a characteristic odor. This chemical is primarily used as a fragrance ingredient in the production of perfumes and cosmetics. It is also utilized in the manufacturing of food flavorings and in the pharmaceutical industry. Additionally, 2,6-Dimethylacetophenone is used as an intermediate in the synthesis of various organic compounds. It is important to handle this compound with caution as it can be harmful if ingested, inhaled or comes into contact with the skin.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 6575-13-9 2,6-dimethylbenzonitrile 
• 14920-81-1 methyl 2,6-dimethylbenzoate 
• 917-54-4 methyllithium 
• 19447-06-4 rac-1-(2,6-dimethylphenyl)ethan-1-ol 
• 14765-50-5 2,6-Dimethyl-1-acetyl-cyclohexadien-(1,3) 
• 576-22-7 2-Bromo-m-xylene 
• 75-36-5 acetyl chloride 
• 82204-76-0 1-(2,6-dimethylphenyl)ethanimine 
• 21900-37-8 2,6-dimethylbenzoyl chloride 
• 174279-17-5 (E)-β-<(2,6-dimethylphenyl)dimethylsilyl>styrene 
• 141-78-6 ethyl acetate 
• 108-24-7 acetic anhydride 
• 108-38-3 m-xylene 

Downstream Products

• 2870-04-4 2-ethyl-1,3-dimethylbenzene 
• 99184-32-4 2,2,2-trichloro-1-(2,6-dimethyl-phenyl)-ethanone 
• 19447-06-4 rac-1-(2,6-dimethylphenyl)ethan-1-ol 
• 111159-74-1 2-<1(Z)-(2,6-dimethylphenyl)ethylidene>hydrazinecarboximidamide 
• 111159-75-2 2-[1(E)-(2,6-dimethylphenyl)ethylidene]hydrazinecarboximidamide 
• 74331-74-1 2,6-dimethylphenylacetylene 
• 74331-79-6 1-(2,6-Dimethylphenyl)vinyl chloride 
• 74346-31-9 1,1-Dichloro-1-(2,6-dimethylphenyl)ethane 
• 74331-78-5 α-(2,6-dimethylphenyl)vinyl bromide 
• 2633-42-3 2-bromo-2',6'-dimethylacetophenone 
• 108-38-3 m-xylene 
• 64-19-7 acetic acid 
• 74331-77-4 1-(2,6-Dimethylphenyl)vinyl tosylate 
• 55968-40-6 1-chloro-1-(2,6-dimethylphenyl)ethane 

Relevant articles and documents

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Optimization of inhibitors of the tyrosine kinase EphB4. 2. Cellular potency improvement and binding mode validation by X-ray crystallography

Inhibition of the tyrosine kinase erythropoietin-producing human hepatocellular carcinoma receptor B4 (EphB4) is an effective strategy for the treatment of solid tumors. We have previously reported a low nanomolar ATP-competitive inhibitor of EphB4 discovered in silico by fragment-based high-throughput docking combined with explicit solvent molecular dynamics simulations. Here we present a second generation of EphB4 inhibitors that show high inhibitory potency in both enzymatic and cell-based assays while preserving the appealing selectivity profile exhibited by the parent compound. In addition, respectable levels of antiproliferative activity for these compounds have been obtained. Finally, the binding mode predicted by docking and molecular dynamics simulations is validated by solving the crystal structures of three members of this chemical class in complex with the EphA3 tyrosine kinase whose ATP-binding site is essentially identical to that of EphB4.

Acyl iodides in the reaction of photochemical Friedel-Crafts acylation

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