21424-82-8 Usage
Description
1-(2-hydroxybiphenyl-3-yl)ethanone, also known as 3-Aceto-2-hydroxybiphenyl, is an organic compound with the molecular formula C14H12O2. It is a derivative of biphenyl with a hydroxyl group at the 2nd position and a ketone group at the 3rd position. 1-(2-hydroxybiphenyl-3-yl)ethanone is characterized by its aromatic structure and functional groups, which contribute to its chemical properties and potential applications.
Uses
1. Used in Pharmaceutical Industry:
1-(2-hydroxybiphenyl-3-yl)ethanone is used as a reactant or reagent for the synthesis of flavonoids, which are a class of plant secondary metabolites with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. The compound's aromatic structure and functional groups make it a valuable building block in the development of these bioactive compounds.
2. Used in Biochemical Research:
In the field of biochemistry, 1-(2-hydroxybiphenyl-3-yl)ethanone serves as a reagent in the synthesis of nonselective inhibitors of trypsin-like serine proteases. These inhibitors are essential tools for studying the function and regulation of proteases, which are enzymes that play crucial roles in various biological processes, including digestion, blood clotting, and immune response.
3. Used in Chemical Synthesis:
Due to its unique structure and functional groups, 1-(2-hydroxybiphenyl-3-yl)ethanone can be employed as an intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Its versatility as a synthetic building block makes it a valuable asset in the development of new molecules with potential applications in various industries.
Preparation
Preparation by Fries rearrangement of 2-acetoxybiphenyl with aluminium chloride,without solvent between 130° and 160°in boiling o-dichlorobenzene for 30 min (15%).
Check Digit Verification of cas no
The CAS Registry Mumber 21424-82-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,4,2 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 21424-82:
(7*2)+(6*1)+(5*4)+(4*2)+(3*4)+(2*8)+(1*2)=78
78 % 10 = 8
So 21424-82-8 is a valid CAS Registry Number.
21424-82-8Relevant articles and documents
De Novo Synthesis of Tricyclic 5,5-Benzannulated Spiroketals
Rao, Maddali L. N.,Islam, Sk Shamim
, p. 3944 - 3948 (2021)
The synthesis of tricyclic 5,5-benzannulated spiroketal scaffolds was accomplished from 2′-hydroxyacetophenones and gem-dibromoalkenes involving a one-pot domino strategy. The hitherto unknown transformation afforded the tricyclic 5,5-benzannulated spirok
Lithiation of a silyl ether: Formation of an ortho-fries hydroxyketone
Lo, Hong-Jay,Lin, Chin-Yin,Tseng, Mei-Chun,Chein, Rong-Jie
supporting information, p. 9026 - 9029 (2014/09/17)
A hydroxy-directed alkylation of an N,N-diethylarylamide using CIPE-assisted α-silyl carbanions (CIPE=complex-induced proximity effect) has been developed using a simple reagent combination of LDA (lithium diisopropylamide) and chlorosilane. A study of the mechanism, and the application of the procedure to an anionic Snieckus-Fries rearrangement for a highly efficient synthesis of the potent phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, are reported.
WB4101-related compounds: New, subtype-selective α1- adrenoreceptor antagonists (or inverse agonists?)
Pallavicini, Marco,Budriesi, Roberta,Fumagalli, Laura,Ioan, Pierfranco,Chiarini, Alberto,Bolchi, Cristiano,Ugenti, Maria Paola,Colleoni, Simona,Gobbi, Marco,Valoti, Ermanno
, p. 7140 - 7149 (2007/10/03)
Our previous structure-affinity relationship study had considered the enantiomers of the naphthodioxane, tetrahydronaphthodioxane, and 2-methoxy-1-naphthoxy analogues (compounds 1, 3, and 2, respectively) of 2-(2,6-dimethoxyphenoxyethylaminomethyl)-1,4-be
