214759-95-2

Basic information

• Product Name: N-METHOXY-N-METHYL-1H-INDOLE-3-CARBOXAMIDE
• Synonyms: N-METHOXY-N-METHYL-1H-INDOLE-3-CARBOXAMIDE
• CAS NO: 214759-95-2
• Molecular Formula: C11H12N2O2
• Molecular Weight: 204.23
• Mol File: 214759-95-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-METHOXY-N-METHYL-1H-INDOLE-3-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHOXY-N-METHYL-1H-INDOLE-3-CARBOXAMIDE(214759-95-2)
• EPA Substance Registry System: N-METHOXY-N-METHYL-1H-INDOLE-3-CARBOXAMIDE(214759-95-2)

Safety Data

• Hazardous Substances Data: 214759-95-2(Hazardous Substances Data)

Usage

General Description

N-Methoxy-N-methyl-1H-indole-3-carboxamide is a compound with the chemical formula C12H14N2O2. It is an amide derivative of indole, a heterocyclic compound found in many natural products and pharmaceuticals. This chemical has been studied for its potential biological and pharmacological properties, including its potential as an anticancer agent. It may also have applications in the synthesis of novel pharmaceutical compounds or as a building block in organic chemistry. Further research is needed to fully understand the potential uses and effects of N-methoxy-N-methyl-1H-indole-3-carboxamide.

Upstream product

• 771-50-6 1H-indole-3-carboxylic acid 
• 79-37-8 oxalyl dichloride 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 3973-08-8 Thiazole-4-carboxylic acid 
• 675606-20-9 1-(tert-butoxycarbonyl)-1H-indole-3-carboxylic acid 

Downstream Products

• 448906-42-1 ITE 

Relevant articles and documents

PROCESSES FOR THE PREPARATION OF ARYL HYDROCARBON RECEPTOR LIGANDS

The present disclosure relates to the preparation of methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate (ITE) and related compounds with high yield, purity, and scalability. The processes apply the use of a Weinreb amide intermediate as a scaffold for the preparation of ITE and structural analogs.

5-HT4 receptor antagonist

Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein X is a monocyclic or polycyclic aromatic group, Z is of sub-formula (h), (j) or (k): STR1 wherein n1 is 1, 2, 3 or 4; n2 is 0, 1, 2, 3 or 4; n3 is 2, 3, 4 or 5; q is 0, 1, 2 or 3; p is 0, 1 or 2; m is 0, 1 or 2; R5 is hydrogen, C1-12 alkyl, aralkyl or R5 is (CH2)z --R10 wherein z is 2 or 3 and R10 is selected from cyano, hydroxyl, C1-6 alkoxy, phenoxy, C(O)C1-6 alkyl, COC6 H5, --CONR11 R12, NR11 COR12, SO2 NR11 R12 or NR11 SO2 R12 wherein R11 and R12 are hydrogen or C1-6 alkyl; or R5 is straight or branched chain alkylene of chain length 1-6 carbon atoms terminally substituted by aryl, 3 to 8 membered cycloalkyl, 3 to 8 membered heterocyclyl, 5 or 6 membered monocyclic heteroaryl or 9 or 10 membered fused bicyclic heteroaryl linked through carbon, C2-7 alkoxycarbonyl, or secondary or tertiary hydroxy substituted C1-6 alkyl; and R6, R7 and R8 are independently hydrogen or C1-6 alkyl; and R9 is hydrogen or C1-10 alkyl; and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders are provided.