21505-06-6

Basic information

• Product Name: N³-benzyl-1H-1,2,4-triazole-3,5-diamine
• Synonyms: N³-benzyl-1H-1,2,4-triazole-3,5-diamine
• CAS NO: 21505-06-6
• Molecular Weight: 189.22
• Mol File: 21505-06-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N³-benzyl-1H-1,2,4-triazole-3,5-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N³-benzyl-1H-1,2,4-triazole-3,5-diamine(21505-06-6)
• EPA Substance Registry System: N³-benzyl-1H-1,2,4-triazole-3,5-diamine(21505-06-6)

Safety Data

• Hazardous Substances Data: 21505-06-6(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 5863-81-0 N-Benzyl-N'-cyan-S-methyl-isothioharnstoff 
• 100-46-9 benzylamine 
• 110821-27-7 N-benzyl-N'-cyano-O-phenylisourea 
• 5863-81-0 methyl N-benzyl-N′-cyanocarbamimidothioate 

Downstream Products

• 1453125-18-2 7-amino-2-benzylamino-1,2,4-triazolo[1,5-a][1,3,5]triazine 
• 1252803-87-4 6-(3-acetylphenyl)-3-benzylamino-[1,2,4]triazolo[4,3-a]pyrimidine 
• 1252803-86-3 3-benzylamino-6-bromo-[1,2,4]triazolo[4,3-a]pyrimidine 
• 135369-55-0 10-Benzyl-7,8-dihydro-2-benzylamino-9H,10H-thiopyrano<3,2-d>-1,2,4-triazolo<1,5-a>pyrimidin-5-one 
• 144431-43-6 2-benzylamino-5-chloro-6,7,8,9-tetrahydro-1,2,4-triazolo[5,1-b]quinazoline 
• 144457-65-8 2-benzylamino-6,7,8,9-tetrahydro-1,2,4-triazolo[5,1-b]quinazolin-5(10H)-one 
• 128626-85-7 2-Benzylamino-5-chloromethyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one 
• 128626-90-4 2-Benzylamino-6-chloro-5-methyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one 
• 110984-76-4 N-(5-Benzylamino-2H-[1,2,4]triazol-3-yl)-acetamide 

Relevant articles and documents

Photoresponsive Molecular Switch for Regulating Transmembrane Proton-Transfer Kinetics

To control proton delivery across biological membranes, we synthesized a photoresponsive molecular switch and incorporated it in a lipid layer. This proton gate was reversibly activated with 390 nm light (Z-isomer) and then deactivated by 360 nm irradiation (E-isomer). In a lipid layer this stimuli responsive proton gate allowed the regulation of proton flux with irradiation to a lipid-buried O2 reduction electrocatalyst. Thus, the catalyst was turned on and off with the E-to-Z interconversion. This light-induced membrane proton delivery system may be useful in developing any functional device that performs proton-coupled electron-transfer reactions.

SUBSTITUTED 5-METHYL-[1, 2, 4] TRIAZOLO [1,5-A) PYRIMIDIN-2-AMINE COMPOUNDS AS PDE2 INHIBITORS

The invention provides a chemical entity of Formula (I): (I), wherein R1, R2, R3, and R4, have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by PDE2 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma- dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including hematological, cardiovascular, gastroenterological, and dermatological disorders.

Synthesis of 5,7-diamino1,2,4 triazolo[1,2-a1,3,5 triazines via annulation of 1,3,5-triazine ring onto 3(5)-amino-1,2,4-triazoles

The 5,7-diamino[1,2,4]triazoeo[1,5-a][1,3,5]triazines were synthesized by cyclocondensation of 3(5)-amino-1,2,4-triazoles with cyanoguanidine. The substituted 3(5)-amino-1,2,4-triazoles were prepared from corresponding hydrazides and S-methylisothiourea via ring closure of the intermediate acylaminoguanidines. The 3,5-diamino-1,2,4-triazoles were prepared using partial aminolysis of dimethyl N-cyanodithiocarbonimidate followed by cyclization of the obtained N-substituted N′-cyano-S-methylisothioureas with hydrazine. The structures of the prepared compound were confirmed using NMR spectral data.