21550-48-1

Basic information

• Product Name: 2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID
• Synonyms: 6-ACETAMIDONICOTINIC ACID;6-(ACETYLAMINO)NICOTINIC ACID;2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID;6-(Acetylamino)nicotinic acid 95%;2-Acetamido-5-pyridinecarboxylic acid ,97%;6-acetamidopyridine-3-carboxylic acid;2-Acetamidopyridine-5-carboxylic acid;6-(Acetylamino)nicotinic acid, 6-(Acetylamino)pyridine-3-carboxylic acid
• CAS NO: 21550-48-1
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.16
• Product Categories: Amines;blocks;Carboxes;Pyridines
• Mol File: 21550-48-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 276-278
• Boiling Point: 484 °C at 760 mmHg
• Flash Point: 246.5 °C
• Appearance: /
• Density: 1.404g/cm³
• Vapor Pressure: 3.52E-10mmHg at 25°C
• Refractive Index: 1.628
• Storage Temp.: 2-8°C
• PKA: 14.18±0.70(Predicted)
• CAS DataBase Reference: 2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID(21550-48-1)
• EPA Substance Registry System: 2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID(21550-48-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 21550-48-1(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C8H8N2O3/c1-5(11)10-7-3-2-6(4-9-7)8(12)13/h2-4H,1H3,(H,12,13)(H,9,10,11)

Upstream product

• 4931-47-9 N-(5-methylpyridin-2-yl)acetamide 
• 3167-49-5 6-aminonicotinic acid 
• 108-24-7 acetic anhydride 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 

Downstream Products

• 3167-49-5 6-aminonicotinic acid 
• 36052-24-1 methyl 6-aminonicotinoate 
• 329-89-5 6-aminonicotinic amide 
• 98953-23-2 6-acetamide-nicotinic acid methyl ester 
• 77837-05-9 6-acetylamino-nicotinic acid amide 
• 54929-66-7 6-amino-N-(1-cyclohexyl-pyrrolidin-2-ylmethyl)-nicotinamide 
• 54929-67-8 6-amino-N-(1-phenyl-pyrrolidin-2-ylmethyl)-nicotinamide 
• 54929-72-5 6-amino-N-[1-(3-phenyl-propyl)-pyrrolidin-2-ylmethyl]-nicotinamide 
• 55087-51-9 6-amino-N-[1-(1-methyl-2-phenyl-ethyl)-pyrrolidin-2-ylmethyl]-nicotinamide 
• 54929-73-6 2-(6-amino nicotinamidomethyl)-1-(3,3-diphenylpropyl) pyrrolidine 
• 1027352-24-4 6-acetamido-N-[2-methyl-5-(4-phenylpiperidine-1-carbonyl)phenyl]pyridine-3-carboxamide 

Relevant articles and documents

Synthesis and crystallographic analysis of short pyridine-based oligoamides as DNA-targeting supramolecular binders

In this study, the synthesis of the pyridine peptides 1-4, formed from amino-picolinic acid, and pyridine peptide 5, made from coupling of a mono-protected pyridine diamine to a mono-protected pyridine dicarboxylic acid and the X-ray crystallographic structures of 1 and 5 are discussed, along with their supramolecular interactions in the solid state. The structure of these compounds showed that they possess concave appearance which can be employed to bind to nucleic acids through multiple hydrogen bonding, which would facilitate the formation of helical-based pyridine oligoamides as novel DNA-binding molecules. This was proven by carrying out DNA denaturation studies and ethidium displacement assay on 5, but, by using MTT assays, 5 was shown to be cytotoxic against drug-resistant chronic myeloid leukaemia K562 cell-line.

DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS

Compounds of formula (I) which are nicotinamide phosphoribosyltransferase (NAMPT) inhibitors and their use for the treatment of hyperproloferative diseases and/or disorders responsive to induction of cell death.

INHIBITORS OF HISTONE DEACETYLASE

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.