21572-56-5

Basic information

• Product Name: N-(3-hydroxyphenyl) morpholine-4-carboxylamide
• Synonyms: N-(3-hydroxyphenyl) morpholine-4-carboxylamide
• CAS NO: 21572-56-5
• Molecular Weight: 222.244
• Mol File: 21572-56-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-hydroxyphenyl) morpholine-4-carboxylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-hydroxyphenyl) morpholine-4-carboxylamide(21572-56-5)
• EPA Substance Registry System: N-(3-hydroxyphenyl) morpholine-4-carboxylamide(21572-56-5)

Safety Data

• Hazardous Substances Data: 21572-56-5(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 787591-43-9 2-(3-isocyanatophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 210907-84-9 3-aminophenylboronic acid pinacolate 

Relevant articles and documents

Synthesis and antitumor activity of novel pyridino[2,3-d]pyrimidine urea derivatives

A series of novel N-(3-((6-bromopyrido[2,3-d]pyrimidin-4-yl)oxy)phenyl)pyrrolidine-1-carboxamide and 1-(3-((6-bromopyrido[2,3-d]pyrimidin-4-yl)oxy)phenyl)-3-propylurea derivatives were synthesized. Their antitumor activities against human breast carcinoma cells (MCF-7) and human colon cancer cells (HCT-116) in vitro were evaluated, using sorafenib as a positive control drug. Anticancer bioassays indicated that several compounds exhibited appreciable anticancer activity against MCF-7 and HCT-116 cells. Particularly, compounds 9g and 8b demonstrated the most significant inhibitory effect against HCT-116 and MCF-7 cells, with inhibition ratios of 25.56% and 26.46%, respectively. Additionally, the synthesized pyridine[2,3-d]pyrimidine derivatives containing a urea group moieties exhibited antitumor activities against MCF-7 and HCT-116 cells in vitro.