21578-46-1

Basic information

• Product Name: 1-(2-aMinophenyl)-1-phenylthiourea
• Synonyms: 1-(2-aMinophenyl)-1-phenylthiourea
• CAS NO: 21578-46-1
• Molecular Formula: C₁₃H₁₃N₃S
• Molecular Weight: 243.32742
• Mol File: 21578-46-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 147-148 °C(Solv: ethanol (64-17-5))
• Boiling Point: 394.2°Cat760mmHg
• Flash Point: 192.2°C
• Appearance: /
• Density: 1.351g/cm³
• Vapor Pressure: 2.02E-06mmHg at 25°C
• Refractive Index: 1.794
• PKA: 12.21±0.70(Predicted)
• CAS DataBase Reference: 1-(2-aMinophenyl)-1-phenylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-aMinophenyl)-1-phenylthiourea(21578-46-1)
• EPA Substance Registry System: 1-(2-aMinophenyl)-1-phenylthiourea(21578-46-1)

Safety Data

• Hazardous Substances Data: 21578-46-1(Hazardous Substances Data)

Usage

Description

1-(2-aminophenyl)-1-phenylthiourea, also known as APTU, is a chemical compound belonging to the class of thioureas. It is widely recognized for its potent inhibitory effects on endocannabinoid metabolism, particularly through the inhibition of the enzyme fatty acid amide hydrolase (FAAH). This action results in elevated endocannabinoid levels, which are linked to a range of physiological and behavioral effects.

Uses

Used in Biomedical and Pharmaceutical Research:
APTU is utilized as a research tool in biomedical and pharmaceutical studies, specifically for investigating the role of endocannabinoid metabolism and its associated enzymes. Its ability to inhibit FAAH makes it a valuable compound for understanding the endocannabinoid system's impact on various physiological processes.
Used in Pain Management:
In the field of pain management, APTU is considered for its potential therapeutic applications. By increasing endocannabinoid levels, it may contribute to the modulation of pain perception, offering a possible avenue for the development of novel analgesic treatments.
Used in Anxiety Treatment:
APTU's impact on the endocannabinoid system also extends to the realm of anxiety treatment. The modulation of endocannabinoid levels by APTU may help in alleviating anxiety symptoms, providing a potential therapeutic approach for individuals suffering from anxiety disorders.
Used in Neurological Disorders:
Due to the endocannabinoid system's involvement in various neurological functions, APTU is studied for its potential applications in the treatment of neurological disorders. The modulation of endocannabinoid levels through APTU's inhibitory action on FAAH may offer new insights and treatment options for neurological conditions.

InChI:InChI=1/C13H13N3S/c14-11-8-4-5-9-12(11)16-13(17)15-10-6-2-1-3-7-10/h1-9H,14H2,(H2,15,16,17)

Upstream product

• 64-17-5 ethanol 
• 103-72-0 phenyl isothiocyanate 
• 95-54-5 1,2-diamino-benzene 
• 62-53-3 aniline 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 

Downstream Products

• 31090-88-7 N'-allyl-N'''-phenyl-N,N''-o-phenylene-bis-thiourea 
• 33077-30-4 (1H-benzo[1,2,5]thiadiazin-3-yl)-phenyl-amine 
• 24694-06-2 1-(N-phenylthiocarbamoyl)-1H-benzotriazole 
• 75644-23-4 2-Thioxo-2,3-dihydro-benzoimidazole-1-carbothioic acid phenylamide 
• 90714-96-8 3-Phenyl-1-thia-3,4a,9-triaza-fluorene-2,4-dithione 
• 62-53-3 aniline 
• 1338782-98-1 (E)-1-(2-(3,5-dibromo-2-hydroxybenzylideneamino)phenyl)-3-phenylthiourea 
• 1338783-01-9 (E)-1-(2-(4-chlorobenzylideneamino)phenyl)-3-phenylthiourea 
• 1338783-03-1 (E)-1-(2-(4-methoxybenzylideneamino)phenyl)-3-phenylthiourea 
• 1338783-02-0 (E)-1-(2-(4-bromobenzylideneamino)phenyl)-3-phenylthiourea 
• 1338782-99-2 (E)-1-(2-(5-chloro-2-hydroxybenzylideneamino)phenyl)-3-phenylthiourea 
• 1338783-00-8 (E)-1-(2-(5-bromo-2-hydroxybenzylideneamino)phenyl)-3-phenylthiourea 
• 1340588-41-1 N-[4-ferrocenyl-2-methyl-4-oxobut-1-enyl]-N'-phenylthiourea 
• 1401033-00-8 N¹-[N-(4-nitrophenyl)thiocarbamoyl]-N²-[N-phenylthiocarbamoyl]-1,2-diaminobenzene 

Relevant articles and documents

Novel synthesized azo-benzylidene-thiourea as dual naked-eye chemosensor for selective detection of Hg2+ and CNˉ ions

Seven novel chemosensors contain azo chromophore and phenylthiourea, were synthesized and applied as colorimetric probes in aqueous solutions of dimethyl sulfoxide. The anion recognition studies exhibited that the synthesized azo dye derivatives act as a

Potassium Periodate Mediated Oxidative Cyclodesulfurization toward Benzofused Nitrogen Heterocycles

A convenient oxidative cyclodesulfurization method toward the synthesis of benzofused nitrogen heterocycles using inexpensive and readily available potassium periodate as an oxidant was developed. Upon treating isothiocyanates with ortho -substituted anilines bearing N, N -, N, O -, and N, S -bis-nucleophiles, followed by an intramolecular cyclization of the in situ generated monothioureas, substituted 2-aminobenzazole series were rapidly accessible in good to excellent yields. The protocol can accommodate various substituents on both substrates while allowing more efficient, greener, and operational simpler process relative to other oxidative coupling reactions. Tetracyclic quinazolinone derivatives were also afforded in high yields in a single preparative step and chromatography-free.

Click mechanochemistry: Quantitative synthesis of "ready to use" chiral organocatalysts by efficient two-fold thiourea coupling to vicinal diamines

Mechanochemical methods of neat grinding and liquid-assisted grinding have been applied to the synthesis of mono- and bis(thiourea)s by using the click coupling of aromatic and aliphatic diamines with aromatic isothiocyanates. The ability to modify the re