215790-29-7 Usage
Description
TERT-BUTYL TRANS-4-(2-OXOETHYL)CYCLOHEXYLCARBAMATE, also known as N-[trans-4-(2-Oxoethyl)cyclohexyl]carbamic Acid 1,1-Dimethylethyl Ester, is an organic compound that serves as a crucial intermediate in the pharmaceutical industry. It is characterized by its unique chemical structure, which allows it to be used in the synthesis of various drugs.
Uses
Used in Pharmaceutical Industry:
TERT-BUTYL TRANS-4-(2-OXOETHYL)CYCLOHEXYLCARBAMATE is used as an intermediate for the synthesis of Cariprazine, a novel antipsychotic medication. Cariprazine acts on dopamine D3/D2 receptors, making it an important treatment option for patients with various psychiatric disorders.
As an intermediate in the synthesis of Cariprazine (C183490), TERT-BUTYL TRANS-4-(2-OXOETHYL)CYCLOHEXYLCARBAMATE plays a vital role in the development of this innovative antipsychotic drug. Its unique chemical properties enable the creation of a medication that can effectively target and modulate dopamine receptors, providing relief for individuals suffering from mental health conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 215790-29-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,5,7,9 and 0 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 215790-29:
(8*2)+(7*1)+(6*5)+(5*7)+(4*9)+(3*0)+(2*2)+(1*9)=137
137 % 10 = 7
So 215790-29-7 is a valid CAS Registry Number.
215790-29-7Relevant articles and documents
C-N bond formation by consecutive continuous-flow reductions towards a medicinally relevant piperazine derivative
éles, János,Bana, Péter,Fül?p, Zsolt,Greiner, István
, (2021)
A new, continuous-flow consecutive reduction method was developed for the C-N bond formation in the synthesis of the key intermediate of the antipsychotic drug cariprazine. The two-step procedure consists of a DIBAL-H mediated selective ester reduction conducted in a novel, miniature alternating diameter reactor, followed by reductive amination using catalytic hydrogenation on 5% Pt/C. The connection of the optimized modules was accomplished using an at-line extraction to prevent precipitation of the aluminum salt byproducts.
CEREBLON BINDING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
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Paragraph 0459, (2022/01/12)
Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, A, A′, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.
Preparation method of cariprazine
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Paragraph 0092-0095, (2020/07/02)
The invention provides a preparation method of cariprazine, which comprises the following steps: reacting trans-N-tert-butyloxycarbonyl-4-(2-(4-(2,3-dichlorophenyl)-piperazine-1-yl)-ethyl)-cyclohexylamine with dimethylamine under the conditions of an orga
