2158-03-4Relevant articles and documents
Sequential base-promoted annulation/palladium-catalyzed domino 1,5-enyne arylation and vinylation of α-propargylaminohydrazones
Rossi, Elisabetta,Arcadi, Antonio,Abbiati, Giorgio,Attanasi, Orazio A.,De Crescentini, Lucia
, p. 1400 - 1402 (2002)
Stereoselective dominos: Cascade reactions of easily accessible α-propargylaminohydrazones 1 represent a simple and efficient method for the preparation of pyrazolones 3.
Regioselective Formal [3+2] Cycloadditions of Urea Substrates with Activated and Unactivated Olefins for Intermolecular Olefin Aminooxygenation
Wu, Fan,Alom, Nur-E,Ariyarathna, Jeewani P.,Na?, Johannes,Li, Wei
supporting information, p. 11676 - 11680 (2019/07/31)
A new class of intermolecular olefin aminooxygenation reaction is described. This reaction utilizes the classic halonium intermediate as a regio- and stereochemical template to accomplish the selective oxyamination of both activated and unactivated alkenes. Notably, urea chemical feedstock can be directly introduced as the N and O source and a simple iodide salt can be utilized as the catalyst. This formal [3+2] cycloaddition process provides a highly modular entry to a range of useful heterocyclic products with excellent selectivity and functional-group tolerance.
A practically simple, catalyst free and scalable synthesis of: N -substituted ureas in water
Tiwari, Lata,Kumar, Varun,Kumar, Bhuvesh,Mahajan, Dinesh
, p. 21585 - 21595 (2018/06/26)
A practically simple, mild and efficient method is developed for the synthesis of N-substituted ureas by nucleophilic addition of amines to potassium isocyanate in water without organic co-solvent. Using this methodology, a variety of N-substituted ureas (mono-, di- and cyclic-) were synthesized in good to excellent yields with high chemical purity by applying simple filtration or routine extraction procedures avoiding silica gel purification. The developed methodology was also found to be suitable for gram scale synthesis of molecules having commercial application in large volumes. The identified reaction conditions were found to promote a unique substrate selectivity from a mixture of two amines.