2161-68-4

Basic information

• Product Name: METHYL-(4-METHYL-THIAZOL-2-YL)-AMINE HYDROCHLORIDE
• Synonyms: METHYL-(4-METHYL-THIAZOL-2-YL)-AMINE HYDROCHLORIDE;4-Methyl-2-(MethylaMino)thiazole;Methyl-(4-methyl-thiazol-2-yl)-amine;N,4-Dimethylthiazol-2-amine
• CAS NO: 2161-68-4
• Molecular Formula: C5H9ClN2S
• Molecular Weight: 128.2
• Mol File: 2161-68-4.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: METHYL-(4-METHYL-THIAZOL-2-YL)-AMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL-(4-METHYL-THIAZOL-2-YL)-AMINE HYDROCHLORIDE(2161-68-4)
• EPA Substance Registry System: METHYL-(4-METHYL-THIAZOL-2-YL)-AMINE HYDROCHLORIDE(2161-68-4)

Safety Data

• Hazardous Substances Data: 2161-68-4(Hazardous Substances Data)

Usage

General Description

Methyl-(4-methyl-thiazol-2-yl)-amine hydrochloride is a chemical compound with the molecular formula C5H10ClN3S. It is a derivative of thiazole and is commonly used as a reagent in organic synthesis. METHYL-(4-METHYL-THIAZOL-2-YL)-AMINE HYDROCHLORIDE is often utilized in the pharmaceutical industry for the production of various drugs and has also been studied for its potential antifungal and antibacterial properties. Methyl-(4-methyl-thiazol-2-yl)-amine hydrochloride is a white crystalline solid that is soluble in water and other polar solvents, making it a versatile and useful compound in research and industrial applications.

Upstream product

• 7336-53-0 N-methyl-N-(4-methyl-thiazol-2-yl)-acetamide 
• 598-52-7 1-(methyl)-thiourea 
• 78-95-5 chloroacetone 
• 110960-25-3 4-methyl-2-(N-methyl)trifluoroacetamidothiazole 
• 111558-97-5 <2-Hydroxy-2-(4-methyl-2-methylamino-5-thiazolyl)ethyl>phosphonsaeure-diethylester 
• 67-64-1 acetone 
• 7647-01-0 hydrogenchloride 
• 861517-60-4 (5-ethoxy-4-methyl-4,5-dihydro-thiazol-2-yl)-methyl-amine 
• 106-96-7 propargyl bromide 
• 1603-91-4 4-methylthiazol-2-ylamine 
• 77-78-1 dimethyl sulfate 
• 1694-29-7 3-chloropentane-2,4-dione 

Downstream Products

• 859479-11-1 N-methyl-N-[4-methyl-5-(4-nitro-phenylsulfanyl)-thiazol-2-yl]-acetamide 
• 878890-10-9 5-bromo-N,4-dimethylthiazol-2-amine 
• 57980-82-2 1,3-dimethyl-1-(4-methyl-thiazol-2-yl)-thiourea 
• 2161-61-7 (5-cyclohexyl-4-methyl-thiazol-2-yl)-methyl-amine 
• 860180-85-4 methyl-[4-methyl-5-(4-nitro-benzenesulfonyl)-thiazol-2-yl]-amine 
• 860180-87-6 N-methyl-N-[4-methyl-5-(4-nitro-benzenesulfonyl)-thiazol-2-yl]-acetamide 
• 1391736-87-0 C₁₈H₁₇N₃OS₂ 
• 1391736-89-2 C₁₈H₁₈N₄OS₂ 
• 1391736-91-6 C₁₉H₂₀N₄OS₂ 
• 1421693-25-5 C₁₇H₂₀N₆O₂S₂ 
• 1421693-26-6 C₁₈H₂₂N₆O₂S₂ 
• 1421693-22-2 3-(5-fluoro-4-(4-methyl-2-(methylamino)thiazol-5-yl)pyrimidin-2-ylamino)benzene sulfonamide 

Relevant articles and documents

Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents

Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases involved in cell cycle and transcriptional regulation. CDK9 regulates transcriptional elongation and this unique property has made it a potential target for several diseases. Due to the conserved ATP binding site, designing selective CDK9 inhibitors has been challenging. Here we report our continued efforts in the optimization of 2,4,5-tri-substituted pyrimidine compounds as potent and selective CDK9 inhibitors. The most selective compound 30m was >100-fold selective for CDK9 over CDK1 and CDK2. These compounds showed broad anti-proliferative activities in various solid tumour cell lines and patient-derived chronic lymphocytic leukaemia (CLL) cells. Decreased phosphorylation of the carboxyl terminal domain (CTD) of RNAPII at Ser-2 and down-regulation of anti-apoptotic protein Mcl-1 were confirmed in both the ovarian cancer model A2780 and patient-derived CLL cells.

A method for preparing such CDK inhibitors (by machine translation)

The invention discloses a method for preparing such CDK inhibitors, will be single-methyl thiourea and 1 - N monochloride reaction, 4 - dimethylthiazole - 2 - amine, by bromo reaction to obtain 5 - bromo - N, 4 - dimethylthiazole - 2 - amine, under the action of the catalyst after the with the borate to obtain aromatic borate intermediates; aromatic borate ester intermediate with 2, 4 - dichloro - 5 fluoro uracil in the noble metal catalytic under suzuki coupling reaction to obtain the coupling product to continue after the Buchwald - Hartwig with the aromatic amine in the reaction, ultimately to obtain the target product. (by machine translation)

Domino alkylation-cyclization reaction of propargyl bromides with thioureas/thiopyrimidinones: A new facile synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-α]pyrimidin-5-ones

A new synthesis of 2-aminothiazoles and 5H-thiazolo[ 3,2-α]pyrimidin- 5-ones was developed as a domino alkylation-cyclization reaction of propargyl bromides with thioureas and thiopyrimidinones, respectively. Domino reactions were performed under microwave irradiation leading to desired compounds in a few minutes and high yields. Georg Thieme Verlag Stuttgart.