216104-72-2

Basic information

• Product Name: 1-Benzyl-5-chloro-3-(2-iodo-phenylamino)-6-methyl-1H-pyrazin-2-one
• Synonyms: 1-Benzyl-5-chloro-3-(2-iodo-phenylamino)-6-methyl-1H-pyrazin-2-one
• CAS NO: 216104-72-2
• Molecular Weight: 451.694
• Mol File: 216104-72-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Benzyl-5-chloro-3-(2-iodo-phenylamino)-6-methyl-1H-pyrazin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-5-chloro-3-(2-iodo-phenylamino)-6-methyl-1H-pyrazin-2-one(216104-72-2)
• EPA Substance Registry System: 1-Benzyl-5-chloro-3-(2-iodo-phenylamino)-6-methyl-1H-pyrazin-2-one(216104-72-2)

Safety Data

• Hazardous Substances Data: 216104-72-2(Hazardous Substances Data)

Upstream product

• 615-43-0 2-iodophenylamine 
• 173200-35-6 1-benzyl-3,5-dichloro-6-methylpyrazin-2(1H)-one 

Downstream Products

• 216104-79-9 1-Benzyl-5-chloro-6-methyl-3-(2-phenylethynyl-phenylamino)-1H-pyrazin-2-one 
• 216104-78-8 1-Benzyl-5-chloro-6-methyl-3-(2-trimethylsilanylethynyl-phenylamino)-1H-pyrazin-2-one 

Relevant articles and documents

Synthesis of α-carbolines and β-carbolinones via intramolecular Diels- Alder reactions of 2(1H)-pyrazinones

2(1H)-Pyrazinones bearing a X-(o-C6H4)-C≡C-R moiety (X=NH, NAc) are shown to undergo an intramolecular cycloaddition-elimination reaction on thermolysis in refluxing bromobenzene yielding α-carbolines or β- carbolinones. The product distribution depends strongly on the substitution pattern of the pyrazinone precursors and the solvent used for thermolysis. A high yield and selective formation of β-carbolinones is possible when heating in tetrahydronaphthalene at reflux. Use of acetic anhydride as solvent facilitated the reaction and made it possible to realise a carbolin(on)e unaccessible by thermolysis in the previously mentioned solvents.