216319-90-3

Basic information

• Product Name: Boc-L-Val-nitrile
• Synonyms: (S)-N-BOC-VALINE-NITRILE;n-[(1s)-1-cyano-2-methylpropyl]-carbamic acid 1,1-dimethylethyl ester;BOC-L-VAL-NITRILE;Boc-Val-Nitrile;Carbamic acid, [(1S)-1-cyano-2-methylpropyl]-, 1,1-dimethylethyl ester (9CI);Carbamic acid, N-[(1S)-1-cyano-2-methylpropyl]-, 1,1-dimethylethyl ester;(S)-tert-butyl 1-cyano-2-methylpropylcarbamate
• CAS NO: 216319-90-3
• Molecular Formula: C10H18N2O2
• Molecular Weight: 198.26
• Product Categories: N-BOC
• Mol File: 216319-90-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 303°C
• Flash Point: 137°C
• Appearance: /
• Density: 0.990
• Refractive Index: 1.
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Boc-L-Val-nitrile(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-L-Val-nitrile(216319-90-3)
• EPA Substance Registry System: Boc-L-Val-nitrile(216319-90-3)

Safety Data

• Hazardous Substances Data: 216319-90-3(Hazardous Substances Data)

Usage

General Description

Boc-L-Val-nitrile is a chemical compound that consists of a tert-butoxycarbonyl (Boc) protecting group attached to a leucine amino acid, with a nitrile functional group on the side chain. It is commonly used in peptide synthesis as a building block for creating new peptide molecules. The Boc protecting group is used to temporarily block the reactive functional groups of the leucine amino acid, allowing for selective reactions to occur at specific sites. The nitrile functional group serves as a chemical handle for further modification or conjugation of the peptide molecule. Boc-L-Val-nitrile is a useful tool in the field of organic and medicinal chemistry for the synthesis of complex peptide-based compounds.

InChI:InChI=1/C10H18N2O2/c1-7(2)8(6-11)12-9(13)14-10(3,4)5/h7-8H,1-5H3,(H,12,13)/t8-/m1/s1

Upstream product

• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 271600-32-9 [2-methyl-1-(toluene-4-sulfonyl)-propyl]-carbamic acid tert-butyl ester 
• 35150-08-4 Boc-Val-NH₂ 
• 13734-41-3 t-Boc-L-valine 
• 72-18-4 L-valine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 98807-40-0 Boc-Val-O-COOEt 

Downstream Products

• 400652-49-5 (2S)-N²-(tert-butoxycarbonyl)-3-methyl-1,2-butanediamine 

Relevant articles and documents

Design, synthesis and cytotoxic evaluation of a library of oxadiazole-containing hybrids

The development of hybrid compounds led to the discovery of new pharmacologically active agents for some of the most critical diseases, including cancer. Herein, we describe a new series of oxadiazole-containing structures designed by a molecular hybridiz

One-pot synthesis of orthogonally protected dipeptide selenazoles employing Nα-amino selenocarboxamides and α-bromomethyl ketones

A simple and efficient protocol for the synthesis of selenazole containing dipeptidomimetics using Nα-amino selenocarboxamides and α-bromomethyl ketones is described. All the compounds made were isolated in good yields and fully characterized.

Synthesis of Boc-amino tetrazoles derived from α-amino acids

A simple route for the synthesis of Boc-protected tetrazole analogs of amino acids starting from Nα-Boc amino acids has been described. The [2 + 3] cycloaddition of Boc-α-amino nitrile and sodium azide in the presence of a catalytic amount of zinc bromide yielded the desired tetrazoles in good yields and purity. All the compounds obtained have been characterized by 1H and 13C-NMR and mass spectral studies. Copyright Taylor & Francis Group, LLC.