216502-06-6

Basic information

• Product Name: 2-AMINO-N-(4-FLUORO-PHENYL)-BENZAMIDE
• Synonyms: 2-AMINO-N-(4-FLUORO-PHENYL)-BENZAMIDE;N1-(4-FLUOROPHENYL)-2-AMINOBENZAMIDE;4'-Fluoroanthranilanilide;AIDS093208;AIDS-093208;AQ-360/13224006;Oprea1_352462;ZERO/006434
• CAS NO: 216502-06-6
• Molecular Formula: C₁₃H₁₁FN₂O
• Molecular Weight: 230.24
• Mol File: 216502-06-6.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 307.8±27.0 °C(Predicted)
• Appearance: /
• Density: 1.317±0.06 g/cm3(Predicted)
• PKA: 12.22±0.70(Predicted)
• CAS DataBase Reference: 2-AMINO-N-(4-FLUORO-PHENYL)-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-(4-FLUORO-PHENYL)-BENZAMIDE(216502-06-6)
• EPA Substance Registry System: 2-AMINO-N-(4-FLUORO-PHENYL)-BENZAMIDE(216502-06-6)

Safety Data

• Hazardous Substances Data: 216502-06-6(Hazardous Substances Data)

Usage

Derivative

It is a derivative of benzamide.

Appearance

White solid

Solubility

Sparingly soluble in water and organic solvents

Applications

Used in research as a building block for synthesizing various pharmaceuticals and agrochemicals
Potential applications in the development of new drugs and agricultural products

Structural Properties

Contains an amino group (2-amino), a fluorine atom (4-fluoro), and a phenyl group

Functional Properties

Possesses properties conducive to drug development and agricultural product synthesis

Upstream product

• 118-48-9 isatoic anhydride 
• 371-40-4 4-fluoroaniline 
• 135066-26-1 N-(4-fluorophenyl)-2-nitrobenzamide 
• 610-14-0 2-nitrobenzyl chloride 
• 6018-89-9 nickel(II) acetate tetrahydrate 
• 552-16-9 ortho-nitrobenzoic acid 
• 5344-90-1 2-Aminobenzyl alcohol 
• 21563-73-5 2-aminobenzoyl chloride 
• 118-92-3 anthranilic acid 

Downstream Products

• 331983-26-7 3-(4-fluorophenyl)quinazolin-4-(3H)-one 
• 256430-29-2 4'-Fluoro-2-[(ethoxycarbonyl)amino]benzanilide 
• 16332-89-1 3-(4-Fluorophenyl)quinazoline-2,4(1H,3H)-dione 
• 127662-28-6 para fluoro benzyl-3 tetrahydro-1,2,3,4 quinazoline 
• 1235479-85-2 3-(4-fluorophenyl)-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one 
• 1221176-86-8 C₁₈H₁₇FN₂O₂ 
• 21878-25-1 3'-p-(phenyl)-1'H-spiro[cyclohexane-1,2'-quinazolin]-4'(3,H)-one 
• 1221177-10-1 C₃₂H₂₆F₂N₄O₂ 
• 1385790-11-3 2-((1-acetyl-3-hydroxy-2-oxoindolin-3-yl)amino)-N-(4-fluorophenyl)benzamide 
• 930679-30-4 2-((5,5-dimethyl-3-oxocyclohex-1-en-1-yl)amino)-N-(4-fluorophenyl)benzamide 
• 1403986-70-8 4-(4-fluorophenyl)-1,5-dioxo-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-3a-carboxylic acid 
• 730956-94-2 4-(4-fluorophenyl)-2,3,3a,4-tetrahydro-3a-methylpyrrolo[1,2-a]quinazoline-1,5-dione 
• 1234324-03-8 3a-methyl-4-(4-fluorophenyl)-2,3,3a,4-tetrahydropyrrolo[1,2-a]quinazolin-5(1H)-one 
• 362514-24-7 3-(4-fluorophenyl)benzo[d][1,2,3]triazin-4(3H)-one 

Relevant articles and documents

One-pot synthesis ofN-substituted benzannulated triazolesviastable arene diazonium salts

A mild and effective one-pot synthesis of 1,2,3-benzotriazin-4(3H)-ones and benzothiatriazine-1,1(2H)-dioxide analogues has been developed. The method involves the diazotisation and subsequent cyclisation of 2-aminobenzamides and 2-aminobenzenesulfonamidesviastable diazonium salts, prepared using a polymer-supported nitrite reagent andp-tosic acid. The transformation was compatible with a wide range of aryl functional groups and amide/sulfonamide-substituents and was used for the synthesis of pharmaceutically important targets. The synthetic utility of the one-pot diazotisaton-cyclisation process was further demonstrated with the preparation of an α-amino acid containing 1,2,3-benzotriazin-4(3H)-one.

Electrochemical utilization of methanol and methanol-d4 as a C1 source to access (deuterated) 2,3-dihydroquinazolin-4(1H)-one

Herein, an electrocatalytic protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-one has been disclosed. Methanol is activated and utilized as the C1 source to cyclize with 2-aminobenzamides. This cyclization reaction proceeds conveniently (room temperature and air atmosphere) without any homogeneous metal catalysts, external oxidants, or bases. A wide variety of N,N-disubstituted 2,3-dihydroquinazolin-4(1H)-ones are obtained via this approach. Moreover, when methanol-d4 is used, a deuterated methylene motif is incorporated into the N-heterocycles, providing an efficient approach to the deuterated N-heterocycles.

Sustainable methine sources for the synthesis of heterocycles under metal- and peroxide-free conditions

Alcohols and ethers were identified as sustainable methine sources for synthesizing quinazolinone and benzimidazole derivatives using a combination of TsOH·H2O/O2 and appropriate bis-nucleophiles for the first time. Deuterium labeling studies clearly proved that the C2 hydrogen of the synthesized heterocycles came from the methine source. These unique reaction conditions were successfully applied to the synthesis of echinozolinone (2e′), 2f′ (a common precursor of rutaecarpine and (±) evodiamine), and dimedazole (6d). Notable features of this method include its low toxicity, use of commercial feedstocks as substrates, low cost, broad functional group tolerance and suitability for a wide range of bis-nucleophilic starting materials.