21651-78-5Relevant articles and documents
Asymmetric amination of meso-epoxide with vegetable powder as a low-toxicity catalyst
Asano, Tatsuhiro,Kurata, Hiroyuki,Takeuchi, Yuki,Tsuzaki, Kazuya,Wada, Koichi
, (2020/08/11)
This paper describes the scope and limitation of substrates subjected to asymmetric amination with epoxides catalyzed by a soluble soybean polysaccharide (Soyafibe S-DN), which we recently discovered from the reaction of 1,2-epoxycyclohexane with cyclopropylamine. Various meso-epoxides reacted with various amines afforded the corresponding products with good enantiomeric selectivity. Since it was found that pectin was found to have a catalytic ability after screening commercially available polysaccharides, we studied 33 different vegetable powders having pectic substances, and we found that many vegetable powders showed catalytic ability. These results should guide in using vegetable components as low-toxic catalysts for the production of pharmaceuticals.
Effect of ring-constrained phenylpropyloxyethylamines on sigma receptors
Stavitskaya, Lidiya,Seminerio, Michael J.,Healy, Jason R.,Noorbakhsh, Bahar,Matsumoto, Rae R.,Coop, Andrew
, p. 4923 - 4927 (2013/09/02)
A series of ring-constrained phenylpropyloxyethylamines, partial opioid structure analogs and derivatives of a previously studied sigma (σ) receptor ligand, was synthesized and evaluated at σ and opioid receptors for receptor selectivity. The results of this study identified several compounds with nanomolar affinity at both σ receptor subtypes. Compounds 6 and 9 had the highest selectivity for both σ receptor subtypes, compared to μ opioid receptors. In addition, compounds 6 and 9 significantly reduced the convulsive effects of cocaine in mice, which would be consistent with antagonism of σ receptors.
Design and synthesis of potent antileishmanial cycloalkylidene-substituted ether phospholipid derivatives
Calogeropoulou, Theodora,Angelou, Panagiotis,Detsi, Anastasia,Fragiadaki, Irene,Scoulica, Effie
, p. 897 - 908 (2008/12/20)
Two series of novel ether phospholipids (EPs) have been synthesized. The first includes cyclodecylidene-or cyclopentadecylidene-substituted EPs carrying N,N,N-trimethylammonium or N-methylpiperidino or N-methylmorpholino head groups. The second series enc
