21668-34-8

Basic information

• Product Name: 4-methoxy-3,5-dimethylbenzoyl chloride
• Synonyms: 4-methoxy-3,5-dimethylbenzoyl chloride;3,5-Dimethyl-4-methoxybenzoyl chloride
• CAS NO: 21668-34-8
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.65
• Mol File: 21668-34-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 301.7±37.0 °C(Predicted)
• Appearance: /
• Density: 1.152±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-methoxy-3,5-dimethylbenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-3,5-dimethylbenzoyl chloride(21668-34-8)
• EPA Substance Registry System: 4-methoxy-3,5-dimethylbenzoyl chloride(21668-34-8)

Safety Data

• Hazardous Substances Data: 21668-34-8(Hazardous Substances Data)

Upstream product

• 21553-46-8 4-methoxy-3,5-dimethylbenzoic acid 

Downstream Products

• 1044874-33-0 C₁₉H₂₂N₂O₅ 
• 1126079-24-0 N-(3,5-dibromo-4-hydroxyphenyl)-3,5-dimethyl-4-methoxybenzamide 
• 52489-58-4 2-n-ethyl-3-(4-hydroxy-3,5-dimethylbenzoyl)benzofuran 
• 1315312-35-6 N-(2,4-dichloro-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide 
• 1315456-69-9 2-(4-methoxy-3,5-dimethyl-benzoylamino)-malonic acid diethyl ester 
• 1315456-71-3 sodium 4,6-dihydroxy-5-(4-methoxy-3,5-dimethyl-benzoylamino)-pyrimidine-2-thiolate 
• 1315456-72-4 N-(4,6-dihydroxy-2-methylsulfanyl-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide 
• 1417620-27-9 7-chloro-2-(4-methoxy-3,5-dimethylphenyl)-5-methylsulfanyloxazolo[5,4-d]pyrimidine 
• 1417620-28-0 4-(7-chloro-5-methylsulfanyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenol 
• 1417620-32-6 tert-butyl {4-[5-(2,5-difluorophenoxy)-7-propyloxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetate 
• 1417620-18-8 C₂₄H₂₁F₂N₃O₅ 
• 1417620-33-7 tert-butyl {2,6-dimethyl-4-[7-propyl-5-(3,3,3-trifluoropropoxy)oxazolo[5,4-d]pyrimidin-2-yl]phenoxy}acetate 
• 1417658-82-2 N-(2,6-dichloropyridin-3-yl)-4-methoxy-3,5-dimethylbenzamide 
• 1417658-84-4 5-(2-fluorophenoxy)-2-(4-methoxy-3,5-dimethylphenyl)oxazolo[5,4-b]pyridine 

Relevant articles and documents

Used for the prevention and treatment of cardiovascular diseases

The invention relates to compounds that can be used for adjusting the expression of apolipoprotein A-I (ApoA-I) and usage of the compounds in treating and preventing cardiovascular diseases and related diseases, including the disorder related to cholesterol or lipids such as atherosclerosis.

Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies

Transthyretin (TTR) amyloidogenesis inhibitors are typically composed of two aromatic rings and a linker. We have previously established optimal structures for one aromatic ring and the linker. Herein, we employ a suboptimal linker and an optimal aryl-X substructure to rank order the desirability of aryl-Z substructures-using a library of 56 N-(3,5-dibromo-4-hydroxyphenyl) benzamides. Coconsideration of amyloid inhibition potency and ex vivo plasma TTR binding selectivity data reveal that 2,6, 2,5, 2, 3,4,5, and 3,5 substituted aryls bearing small substituents generate the most potent and selective inhibitors, in descending order. These benzamides generally lack undesirable thyroid hormone receptor binding and COX-1 inhibition activity. Three high-resolution TTR ? inhibitor crystal structures (1.31-1.35 ?) provide insight into why these inhibitors are potent and selective, enabling future structure-based design of TTR kinetic stabilizers.

COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES

The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotei? A-I (ApoA-l), and their use for the treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis.