21676-90-4

Basic information

• Product Name: METHYL 4-PHENYLTHIOPHENE-2-CARBOXYLATE
• Synonyms: METHYL 4-PHENYLTHIOPHENE-2-CARBOXYLATE;BUTTPARK 46\15-23;RARECHEM AL BF 0924
• CAS NO: 21676-90-4
• Molecular Formula: C₁₂H₁₀O₂S
• Molecular Weight: 218.27
• Mol File: 21676-90-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 96-98°C
• Appearance: /
• CAS DataBase Reference: METHYL 4-PHENYLTHIOPHENE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-PHENYLTHIOPHENE-2-CARBOXYLATE(21676-90-4)
• EPA Substance Registry System: METHYL 4-PHENYLTHIOPHENE-2-CARBOXYLATE(21676-90-4)

Safety Data

• Hazardous Substances Data: 21676-90-4(Hazardous Substances Data)

Usage

General Description

Methyl 4-phenylthiophene-2-carboxylate is a chemical compound with the molecular formula C13H10O2S. It is a ester derivative of phenylthiophene carboxylic acid and is often used as an intermediate in the synthesis of various organic compounds. It is a yellow to brown crystalline powder and is commonly used in pharmaceutical and agrochemical research. Methyl 4-phenylthiophene-2-carboxylate is known for its wide range of applications in the field of organic chemistry and is valued for its potential as a building block in the creation of new and innovative molecules.

Upstream product

• 82437-64-7 methyl 3-amino-4-phenyl-2-thiophenecarboxylate 
• 60231-03-0 2-phenyl-3-chloropropenal 
• 2365-48-2 Methyl thioglycolate 
• 1026365-83-2 (1-Methoxycarbonylmethylsulfanyl-3-oxo-2-phenyl-propylsulfanyl)-acetic acid methyl ester 
• 7089-34-1 ((E)-3-Dimethylamino-2-phenyl-allylidene)-dimethyl-ammonium; perchlorate 
• 4432-64-8 hydroxymethylenephenylacetaldehyde 
• 22252-92-2 3-hydroxy-2-phenylacrylonitrile 
• 140-29-4 phenylacetonitrile 
• 62224-16-2 4-bromothiophene-2-carboxylic acid methyl ester 
• 98-80-6 phenylboronic acid 
• 5380-42-7 thiophene-2-carboxylic acid methyl ester 
• 591-50-4 iodobenzene 
• 124-38-9 carbon dioxide 
• 2404-87-7 3-phenylthiophene 

Downstream Products

• 21676-88-0 4-phenyl-2-thiophenecarboxylic acid 
• 79757-76-9 4-phenyl-2-thiophenemethanol 
• 2404-87-7 3-phenylthiophene 
• 26170-87-6 4-phenylthiophene-2-carbaldehyde 
• 107377-26-4 3-phenyl-4H-thiopheno[3,2-b]pyrrole-5-carboxylic acid 
• 107377-25-3 ethyl 3-phenyl-4H-thieno<3,2-b>pyrrole-5-carboxylate 
• 1228581-03-0 methyl 5-bromo-4-phenyl-thiophene-2-carboxylate 
• 1228581-04-1 methyl 5-isopropenyl-4-phenylthiophene-2-carboxylate 

Relevant articles and documents

Ag(I)-Catalyzed C-H Carboxylation of Thiophene Derivatives

CO2utilization is an attractive aspect as it allows the direct conversion of CO2into valuable chemicals. In this regard, direct incorporation of CO2into the C-H bond of heteroaromatic compounds is important due to the ubiquitous structural motifs of the heteroaromatic carboxylic acids. Herein, we report the Ag-catalyzed C-H carboxylation of thiophene derivatives. This new catalytic system involving a phosphine ligand and lithiumtert-butoxide enables the direct carboxylation of thiophenes under mild reaction conditions. Experimental studies revealed that the use oftert-butyl alkoxide is critical for the exergonic formation of an arylsilver intermediate, and the results were further supported by density functional theory calculations.

In-Depth Assessment of the Palladium-Catalyzed Fluorination of Five-Membered Heteroaryl Bromides

A thorough investigation of the challenging Pd-catalyzed fluorination of five-membered heteroaryl bromides is presented. Crystallographic studies and density functional theory (DFT) calculations suggest that the challenging step of this transformation is

3-alkyl or aryl thiophenes from malonaldehyde derivatives

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