216766-12-0 Usage
Description
6-(TRIFLUOROMETHYL)PYRIDIN-3-OL is an organic compound characterized by the presence of a trifluoromethyl group attached to a pyridine ring, with a hydroxyl group at the 3-position. This unique structure endows it with specific chemical properties that make it a valuable intermediate in the synthesis of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
6-(TRIFLUOROMETHYL)PYRIDIN-3-OL is used as a key intermediate in the synthesis of tricyclic dihydroimidazopyrimidone derivatives. These derivatives possess the potential to act as lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitors, which are important targets for the treatment of cardiovascular diseases. By inhibiting Lp-PLA2, these compounds can help regulate inflammatory processes and reduce the risk of atherosclerosis and other related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 216766-12-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,6,7,6 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 216766-12:
(8*2)+(7*1)+(6*6)+(5*7)+(4*6)+(3*6)+(2*1)+(1*2)=140
140 % 10 = 0
So 216766-12-0 is a valid CAS Registry Number.
216766-12-0Relevant articles and documents
Radical-anion coupling through reagent design: hydroxylation of aryl halides
Chechik, Victor,Greener, Andrew J.,James, Michael J.,Oca?a, Ivan,Owens-Ward, Will,Smith, George,Ubysz, Patrycja,Whitwood, Adrian C.
, p. 14641 - 14646 (2021/11/17)
The design and development of an oxime-based hydroxylation reagent, which can chemoselectively convert aryl halides (X = F, Cl, Br, I) into phenols under operationally simple, transition-metal-free conditions is described. Key to the success of this approach was the identification of a reducing oxime anion which can interact and couple with open-shell aryl radicals. Experimental and computational studies support the proposed radical-nucleophilic substitution chain mechanism.
