216879-15-1

Basic information

• Product Name: Cyclohexanecarboxamide, 2-hydroxy-, (1S,2S)- (9CI)
• Synonyms: Cyclohexanecarboxamide, 2-hydroxy-, (1S,2S)- (9CI)
• CAS NO: 216879-15-1
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.18362
• Product Categories: AMIDE
• Mol File: 216879-15-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 352.6±31.0 °C(Predicted)
• Appearance: /
• Density: 1.174±0.06 g/cm3(Predicted)
• PKA: 14.71±0.40(Predicted)
• CAS DataBase Reference: Cyclohexanecarboxamide, 2-hydroxy-, (1S,2S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxamide, 2-hydroxy-, (1S,2S)- (9CI)(216879-15-1)
• EPA Substance Registry System: Cyclohexanecarboxamide, 2-hydroxy-, (1S,2S)- (9CI)(216879-15-1)

Safety Data

• Hazardous Substances Data: 216879-15-1(Hazardous Substances Data)

Upstream product

• 196801-10-2 cis-(1S,2S)-2-hydroxycyclohexane-1-carbonitrile 
• 646-20-8 pimelonitrile 
• 4513-77-3 2-cyanocyclohexanone 
• 936-03-8 (+/-)-cis-2-hydroxy-cyclohexanecarboxylic acid methyl ester 
• 1655-06-7 cis-ethyl 2-hydroxy-cyclohexanoate 
• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 609-69-8 (+/-)-(1R,2S)-cis-2-hydroxy-1-cyclohexanecarboxylic acid 
• 63301-31-5 trans-2-cyanocyclohexanol 
• 125356-62-9 (1R,2S)-2-hydroxycyclohexane-1-carbonitrile 

Relevant articles and documents

Strengthening the Combination between Enzymes and Metals in Aqueous Medium: Concurrent Ruthenium-Catalyzed Nitrile Hydration - Asymmetric Ketone Bioreduction

A dual ruthenium/ketoreductase catalytic system has been developed for the conversion of β-ketonitriles into optically active β-hydroxyamides through an unprecedented hydration/bioreduction cascade process in aqueous medium working in concurrent mode. The ketoreductase-mediated ketone reduction took place with exquisite stereoselectivity and it was simultaneous to the nitrile hydration promoted by the ruthenium catalyst. The overall transformation occurred: (i) employing commercially and readily available catalytic systems (ii) under mild reaction conditions, (iii) with high degree of conversion and excellent stereoselectivity, and (iv) without the need to isolate intermediates and with high final product yields. This genuine process demonstrates the benefits of combining metal and enzymatic catalysis to tackle the limitations arising from each field.

Developing a Biocascade Process: Concurrent Ketone Reduction-Nitrile Hydrolysis of 2-Oxocycloalkanecarbonitriles

A stereoselective bioreduction of 2-oxocycloalkanecarbonitriles was concurrently coupled to a whole cell-catalyzed nitrile hydrolysis in one-pot. The first step, mediated by ketoreductases, involved a dynamic reductive kinetic resolution, which led to 2-hydroxycycloalkanenitriles in very high enantio- and diastereomeric ratios. Then, the simultaneous exposure to nitrile hydratase and amidase from whole cells of Rhodococcus rhodochrous provided the corresponding 2-hydroxycycloalkanecarboxylic acids with excellent overall yield and optical purity for the all-enzymatic cascade.

Dynamic kinetic resolution of 2-oxocycloalkanecarbonitriles: Chemoenzymatic syntheses of optically active cyclic β- and γ-amino alcohols

A series of fungi and yeasts have been tested for the stereoselective bioreduction of 2-oxocycloalkanecar-bonitriles, 1. The yeast Saccharomyces montanus CBS 6772 yielded the corresponding cis-hydroxy nitriles, 2, in >90% ee and de and in high chemical yields. Through simple and efficient procedures, they were transformed into optically active 2-amino and 2-aminomethyl cycloalkanols.