21709-18-2 Usage
Description
Carbonimidic dichloride, (2,6-dichlorophenyl)is an organic compound that serves as an impurity in the pharmaceutical compound clonidine. Clonidine is an α2-adrenergic agonist, which is utilized for its antihypertensive and analgesic properties, particularly for neuropathic pain.
Uses
Used in Pharmaceutical Industry:
Carbonimidic dichloride, (2,6-dichlorophenyl)is used as an impurity in the production of clonidine, an α2-adrenergic agonist. Its presence is significant due to the therapeutic applications of clonidine in treating high blood pressure and neuropathic pain. The compound plays a role in the synthesis process of clonidine, which contributes to its overall effectiveness as a medication.
1. Antihypertensive Applications:
Clonidine, which contains Carbonimidic dichloride, (2,6-dichlorophenyl)as an impurity, is used as an antihypertensive agent. It helps in lowering blood pressure by stimulating the α2-adrenergic receptors, leading to a decrease in heart rate and blood vessel constriction.
2. Analgesic for Neuropathic Pain:
Clonidine, with Carbonimidic dichloride, (2,6-dichlorophenyl)as an impurity, is also utilized as an analgesic for neuropathic pain. It aids in reducing pain signals transmitted by the nervous system, providing relief to patients suffering from various types of neuropathic pain conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 21709-18-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,7,0 and 9 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 21709-18:
(7*2)+(6*1)+(5*7)+(4*0)+(3*9)+(2*1)+(1*8)=92
92 % 10 = 2
So 21709-18-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H3Cl4N/c8-4-2-1-3-5(9)6(4)12-7(10)11/h1-3H
21709-18-2Relevant articles and documents
A preparation method of the clonidine hydrochloride
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, (2018/04/28)
The invention discloses a method for preparing the clonidine hydrochloride, including intermediates 1 synthesis, intermediate 2 synthesis and clonidine hydrochloride synthetic three steps, the present invention in order to 2, 6 - dichloroaniline as raw materials, through the hydroformylation reaction get intermediate 1, "one-pot" get clonidine free base, finally with hydrogen chloride ethanol solution into salt clonidine hydrochloride. By processing the raw material synthetic process, by utilizing the free alkali in the course of refining into salt after adjusting pH, and the clonidine hydrochloride is used for purification of the pulping process control such as ethyl acetate, to obtain a high-purity clonidine hydrochloride preparation method. The method not only improves the product purity and yield, impurity can also effectively control, but also greatly reducing the cost, simplifying the process, is more suitable for industrial production.
A Novel Synthesis of Clonidine, an Anti-Hypertensive Drug from o-Chloronitrobenzene
Ayyangar, N. R.,Brahme, K. C.,Srinivasan, K. V.
, p. 64 - 65 (2007/10/02)
An elegant, cost-effective synthesis of clonidine (4) is reported from readily available starting materials. o-Chlorophenylhydroxylamine (2), obtained from o-chloronitrobenzene, is formylated to N-(2-chlorophenyl)-N-hydroxyformamide (3).In a one-pot procedure, 3 is converted to clonidine by chlorination with thionyl chloride and then with thionyl chloride/sulfuryl chloride, followed by condensation with ethylenediamine.
