21724-88-9

Basic information

• Product Name: 1H-Pyrrole-2,5-dione, 3-(4-chlorophenyl)-1-phenyl-
• CAS NO: 21724-88-9
• Molecular Formula: C16H10ClNO2
• Molecular Weight: 283.714
• Mol File: 21724-88-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-2,5-dione, 3-(4-chlorophenyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2,5-dione, 3-(4-chlorophenyl)-1-phenyl-(21724-88-9)
• EPA Substance Registry System: 1H-Pyrrole-2,5-dione, 3-(4-chlorophenyl)-1-phenyl-(21724-88-9)

Safety Data

• Hazardous Substances Data: 21724-88-9(Hazardous Substances Data)

Upstream product

• 873-73-4 4-n-chlorophenylacetylene 
• 201230-82-2 carbon monoxide 
• 62-53-3 aniline 
• 124-38-9 carbon dioxide 
• 941-69-5 N-phenyl-maleimide 
• 106-47-8 4-chloro-aniline 
• 637-87-6 1-Chloro-4-iodobenzene 
• 17333-85-6 4-chlorophenyldiazonium salt 

Relevant articles and documents

Palladium-catalyzed aerobic oxidative carbonylation of alkynes with amines: a general access to substituted maleimides

A catalytic oxidative carbonylation reaction was developed for the synthesis of polysubstituted maleimides from alkynes and amines with air as a green oxidant. This novel transformation proceeds in the presence of palladium chloride without the need for expensive ligands or additives and has a broad substrate scope affording a variety of maleimides in good to high yields.

Cu/Ag-Cocatalyzed Aerobic Oxidative Amination and CuCl2-Mediated Aerobic Oxidative Chloroamination of Maleimides

An efficient Cu(OAc)2/Ag2CO3-cocatalyzed approach for the synthesis of 3-aminomaleimides and 3-amino-4-indolylmaleimides has been developed with satisfactory yields. A series of primary and secondary amines are compatible with this reaction. In addition, treatment of maleimides with primary amines using 1 equiv. of CuCl2leads to the formation of chloroamination products such as 3-amino-4-chloromaleimides by a radical-type mechanism.