21752-33-0

Basic information

• Product Name: (R)-(+)-N-(1-PHENYLETHYL)SUCCINAMIC ACID
• Synonyms: (R)-4-oxo-4-[(1-phenylethyl)amino]butyric acid;Butanoic acid, 4-oxo-4-(1R)-1-phenylethylamino-;(r)-(+)-n-(α-methylbenzyl)succinamidic acid;(R)-(+)-N-(1-PHENYLETHYL)SUCCINAMIC ACID FOR RESOLUTION OF RACEMATES 98+%;(+)-N-[(R)-α-Methylbenzyl]succinamidic acid;4-Oxo-4-[[(R)-α-methylbenzyl]amino]butanoic acid;N-[(R)-α-Methylbenzyl]succinamidic acid;Einecs 244-567-4
• CAS NO: 21752-33-0
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.25
• EINECS: 244-567-4
• Mol File: 21752-33-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 98-101 °C
• Boiling Point: 470°Cat760mmHg
• Flash Point: 238°C
• Appearance: /
• Density: 1.167g/cm³
• Vapor Pressure: 1.23E-09mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: Store below +30°C.
• PKA: 4.72±0.10(Predicted)
• BRN: 3205512
• CAS DataBase Reference: (R)-(+)-N-(1-PHENYLETHYL)SUCCINAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-N-(1-PHENYLETHYL)SUCCINAMIC ACID(21752-33-0)
• EPA Substance Registry System: (R)-(+)-N-(1-PHENYLETHYL)SUCCINAMIC ACID(21752-33-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 21752-33-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H15NO3/c1-9(10-5-3-2-4-6-10)13-11(14)7-8-12(15)16/h2-6,9H,7-8H2,1H3,(H,13,14)(H,15,16)/t9-/m1/s1

Upstream product

• 108-30-5 succinic acid anhydride 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Downstream Products

• 816431-99-9 C₉H₁₃N*C₁₂H₁₅NO₃ 
• 1227845-02-4 C₉H₁₃N*C₁₂H₁₅NO₃ 

Relevant articles and documents

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Asymmetric induction via metalation of succinic esters and amide using S(+) menthol and R(+) 1-Phenylethylamine as chiral auxiliaries

The synthesis of chiral esters and amides with the involvement of asymmetric induction by using pure chiral auxiliaries such as (1S, 2R, 5R) menthol and L-(+)-1-phenylethylamine is described. The chiral mono, di menthol esters and mono amides of succinic acid were synthesized in good yields. These esters and amides were then subjected to metalation and quenched with different alkyl halides to get α substitution to generate a new chiral center.