21784-73-6

Basic information

• Product Name: 4-IODO-2-NITROPHENOL
• Synonyms: 4-IODO-2-NITROPHENOL
• CAS NO: 21784-73-6
• Molecular Formula: C₆H₄INO₃
• Molecular Weight: 265.01
• Product Categories: Aromatic Phenols
• Mol File: 21784-73-6.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 296.4°C at 760 mmHg
• Flash Point: 133°C
• Appearance: /
• Density: 2.176g/cm³
• Vapor Pressure: 0.000816mmHg at 25°C
• Refractive Index: 1.71
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 4-IODO-2-NITROPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-2-NITROPHENOL(21784-73-6)
• EPA Substance Registry System: 4-IODO-2-NITROPHENOL(21784-73-6)

Safety Data

• Hazardous Substances Data: 21784-73-6(Hazardous Substances Data)

Usage

General Description

4-IODO-2-NITROPHENOL is a chemical compound with the molecular formula C6H4INO3. It is a yellow crystalline solid that is insoluble in water, but soluble in organic solvents. 4-IODO-2-NITROPHENOL is commonly used as an intermediate in the synthesis of various organic compounds and pharmaceuticals. It is also used in the production of dyes, pigments, and pesticides. 4-IODO-2-NITROPHENOL is considered to be toxic and may cause skin and eye irritation upon contact. It is important to handle this compound with caution and to follow proper safety protocols when working with it.

InChI:InChI=1/C6H4INO3/c7-4-1-2-6(9)5(3-4)8(10)11/h1-3,9H

Upstream product

• 540-38-5 p-Iodophenol 
• 121-19-7 roxarsone 
• 364-76-1 4-Fluoro-3-nitroaniline 
• 88-75-5 2-hydroxynitrobenzene 
• 645-00-1 m-iodonitrobenzene 
• 108-95-2 phenol 
• 32707-02-1 thallium(I) 2-nitrophenoxide 
• 7553-56-2 iodine 
• 64-19-7 acetic acid 
• 127-65-1 chloroamine-T 
• 7697-37-2 nitric acid 
• 7664-93-9 sulfuric acid 
• 5307-14-2 2-nitro-1,4-phenylenediamine 
• 533-58-4 2-Iodophenol 

Downstream Products

• 20294-48-8 diiodo-4,6 nitro-2 phenol 
• 99969-17-2 2-amino-4-iodophenol 
• 89488-54-0 4-iodo-2,6-dinitrophenol 
• 88-89-1 2,4,6-Trinitrophenol 
• 52692-09-8 4-iodo-2-nitroanisole 
• 876486-79-2 2-(2,4-dinitro-anilino)-4-iodo-phenol 
• 860584-61-8 2-(2,4-dinitro-phenoxy)-5-iodo-aniline 
• 401899-29-4 C₁₃H₁₀INO₃ 

Relevant articles and documents

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Ruthenium-Catalyzed Tandem Carbene/Alkyne Metathesis/N-H Insertion: Synthesis of Benzofused Six-Membered Azaheterocycles

The Cp*RuCl-based catalyst enables expedient access to a variety of benzofused six-membered azaheterocycles from unprotected o-alkynylanilines and trimethylsilyldiazomethane through an unprecedent tandem carbene/alkyne metathesis/N-H insertion reaction. The transformation takes place under mild reaction conditions (room temperature, 15 min) and with excellent functional group tolerance. The synthetic utility of the final products and a mechanistic rationale are also discussed.

Iodine(III)-Catalyzed Electrophilic Nitration of Phenols via Non-Br?nsted Acidic NO2+ Generation

The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate as a nitro group source. This atom-economic protocol occurs under mild, non-Br?nsted acidic and open-flask reaction conditions with a broad functional-group tolerance including several heterocycles. Density functional theory (DFT) calculations at the (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G) level indicated that the reaction proceeds through a cationic pathway that efficiently generates the NO2+ ion, which is the nitrating species under neutral conditions.