21821-40-9Relevant articles and documents
Acrylamide derivative and preparation method and application thereof
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Paragraph 0026; 0028; 0030, (2018/07/30)
The invention belongs to the field of chemical medicines, and particularly relates to an acrylamide derivative. The acrylamide derivative adopts a structural general formula as follows: FORMULA. Someembodiments of the acrylamide derivative confirm that th
Discovery of new Gram-negative antivirulence drugs: Structure and properties of novel E. coli WaaC inhibitors
Moreau,Desroy,Genevard,Vongsouthi,Gerusz,Le Fralliec,Oliveira,Floquet,Denis,Escaich,Wolf,Busemann,Aschenbrenner
scheme or table, p. 4022 - 4026 (2009/04/06)
Heptosyltransferases such as WaaC represent promising and attractive targets for the discovery of new Gram-negative antibacterial drugs based on antivirulence mechanisms. We report herein our approach to the identification of the first micromolar inhibitors of WaaC and the preliminary SAR generated from this family of 2-aryl-5-methyl-4-(5-aryl-furan-2-yl-methylene)-2,4-dihydro-pyrazol-3-on es identified by virtual screening.
Structure-activity relationships of novel anti-malarial agents. Part 7: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides with polar moieties
Wiesner, Jochen,Mitsch, Andreas,Jomaa, Hassan,Schlitzer, Martin
, p. 2159 - 2161 (2007/10/03)
In a previous report, we have provided evidence that novel anti-malarial compounds based on 2,5-diaminobenzophenone farnesyltransferase inhibitors might benefit from the presence of a polar moiety at the para position of the terminal phenyl of the arylfur