21855-16-3

Basic information

• Product Name: Ethyl2,6-PyridinedicarboxylateMono
• Synonyms: 6-Ethoxycarbonyl-2-pyridinecarboxylic acid;Methyl dipicolinate;2,6-pyridinediCarbocylic acid monoethyl ester;6-(Ethoxycarbonyl);Ethyl2,6-PyridinedicarboxylateMono;2,6-pyridinedicarboxylatemonoethylester;6-(Ethoxycarbonyl)picolinic acid
• CAS NO: 21855-16-3
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.173
• Mol File: 21855-16-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 116-117℃
• Boiling Point: 396.2 °C at 760 mmHg
• Flash Point: 193.4 °C
• Appearance: /
• Density: 1.304 g/cm³
• Vapor Pressure: 5.47E-07mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.27±0.10(Predicted)
• CAS DataBase Reference: Ethyl2,6-PyridinedicarboxylateMono(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl2,6-PyridinedicarboxylateMono(21855-16-3)
• EPA Substance Registry System: Ethyl2,6-PyridinedicarboxylateMono(21855-16-3)

Safety Data

• Hazardous Substances Data: 21855-16-3(Hazardous Substances Data)

Usage

General Description

Ethyl 2,6-pyridinedicarboxylateMono, also known as ethyl 2,6-pyridinedicarboxylate, is a chemical compound that is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is a diester derivative of pyridine-2,6-dicarboxylic acid and is often utilized as a precursor in the production of various drugs and pesticides. Ethyl2,6-PyridinedicarboxylateMono is known for its ability to participate in a range of chemical reactions, making it a versatile and valuable intermediate in organic synthesis. It is also used in the manufacturing of dyes, pigments, and other industrial products. Overall, ethyl 2,6-pyridinedicarboxylateMono plays a crucial role in the synthesis of numerous important compounds and is widely utilized in the pharmaceutical and agricultural industries.

InChI:InChI=1/C9H9NO4/c1-2-14-9(13)7-5-3-4-6(10-7)8(11)12/h3-5H,2H2,1H3,(H,11,12)

Upstream product

• 3739-94-4 2,6-Pyridinedicarbonyl dichloride 
• 64-17-5 ethanol 

Downstream Products

• 1132667-28-7 (S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-((R)-2-(6-(((tert-butoxycarbonyl)amino)methyl)pyridin-2-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate 
• 1197-10-0 6-(hydroxymethyl)pyridine-2-carboxylic acid 
• 1132667-29-8 C₄₂H₄₄N₄O₄S₂ 
• 1204045-59-9 6-[1,3-dioxo-3-(2-hydroxyphenyl)propyl]pyridine-2-carboxylic acid ethyl ester 
• 1038409-59-4 C₁₅H₁₅N₃O₃ 
• 203321-87-3 4-tert-butoxycarbonylamino-1-(6-tert-butoxycarbonylaminopyridin-2-ylmethyl)piperidine 
• 203321-83-9 tert-butyl 6-(hydroxymethyl)-2-pyridinylcarbamate 

Relevant articles and documents

Synthesis, crystal structure, and different local conformations of pyridine-imide oligomers

In this article, we report a new approach toward synthesis of pyridine-imide oligomers (PIOs). Using this approach, both dimer and trimer were one-pot synthesized from acylation of monomeric monoamide with monomeric dichloride. The yield of trimer was dependent on the alkoxyl terminals: it was 30% for methoyl group, whereas it was 95% for 3-chloro-1-propoxyl terminal. Acylation of dimeric monoamide with monomeric dichloride produced trimer, tetramer, and pentamer in a yield of 34%, 33%, and 28%, respectively. The synthesis was proposed to be mediated through an exchange between pyridine-2-carboxamide and pyridine-2-carbonyl chloride, both forming intramolecular or intermolecular hydrogen-bonds between pyridine-nitrogen and pyridine-2-amide hydrogen atoms. Crystal structure from three trimers with different terminal groups was reported. Analysis on the crystal structures revealed that these three trimers had different local conformations. The different local conformations were originated from the structural tunability of the imide unit in either the coplanarity or bond parameters.