21887-86-5Relevant articles and documents
Organogels formed in various organic solvents by different alkyl L-phenylalanine dihydrazide derivatives
Wang, Chuansheng,Wei, Wei,Li, Zhiyuan,Wang, Xiaohong,Shen, Hua,Sui, Zhitong
, p. 45 - 49 (2012)
A new group of organogelators, L-phenylalanine dihydrazide derivatives were synthesized, which can self-assemble in various organic solvents and turned them into thermally reversible physical supramolecular organogels at extremely low concentrations (2 w
Transformations of β-aryl-N-Cbz-α,β-didehydro-α-amino esters with hydrazine hydrate
Drev, Miha,Gro?elj, Uro?,Svete, Jurij
, p. 623 - 631 (2016/07/06)
Cyclizations of Cbz-protected α,β-didehydro-β-arylalanine esters 1 with excess hydrazine hydrate afforded mixtures of the expected 3-pyrazolidinones 2 and the unexpected 1-amino-5-benzylidenehydantoins 6 and N-Cbz-β-arylalanine hydrazides 7. Presumably, the pyrazolidinones 2 and hydantoins 6 are formed as primary products via competitive 1,2- and 1,4-addition of hydrazine hydrate followed by cyclization, whereas β-arylalanine hydrazides 7 are formed as secondary products via reductive cleavage of the C(5)-N(1) bond in pyrazolidinones 2. The overall selectivity depends on the reaction time and on the β-substituent in the starting dehydroalanine ester 1.
Synthesis and Antitubercular Activity of Novel Amino Acid Derivatives
Da Costa, Cristiane F.,Pinheiro, Alessandra C.,De Almeida, Mauro V.,Lourenco, Maria C.S.,De Souza, Marcus V.N.
experimental part, p. 216 - 222 (2012/04/23)
In this work, 17 new N-acylhydrazone derivatives of amino acids have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. The compounds 8b, 8e, 8f, 9a-d, and 10c exhibited an important minimum inhibitory concentration activity between 12.5 and 50μg/mL, which can be compared with that of the tuberculostatic drug d-cycloserine (20μg/mL). In this work 17 new N-acylhydrazone derivatives of amino acids have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Eight compounds were non-cytotoxic and exhibited an important MIC activity between 12.5 and 50μg/mL, which can be compared with that of the tuberculostatic drug d-cycloserine (20μg/mL).
