21911-88-6

Basic information

• Product Name: methyl 3-(4-chlorophenylamino)propanoate
• Synonyms: methyl 3-(4-chlorophenylamino)propanoate
• CAS NO: 21911-88-6
• Molecular Weight: 213.664
• Mol File: 21911-88-6.mol
• Article Data: 24

Chemical Properties

• Melting Point: 58-60 °C(Solv: ethanol (64-17-5))
• Boiling Point: 128-130 °C(Press: 0.001 Torr)
• Density: 1.229±0.06 g/cm3(Predicted)
• CAS DataBase Reference: methyl 3-(4-chlorophenylamino)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(4-chlorophenylamino)propanoate(21911-88-6)
• EPA Substance Registry System: methyl 3-(4-chlorophenylamino)propanoate(21911-88-6)

Safety Data

• Hazardous Substances Data: 21911-88-6(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 545445-44-1 5,6?dihydro?3?(4?morpholinyl)?1?[4?(2?oxo?1?piperidinyl)phenyl]?2(1H)?pyridone 
• 1190762-11-8 C₉H₉ClN₂O 
• 1450610-32-8 C₁₄H₁₇ClN₂O₃ 
• 1190761-78-4 3-(2-(4-chlorophenylamino)ethyl)-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide 
• 1190761-83-1 tert-butyl 2-(8-carbamoyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazin-3(4H)-yl)ethyl(4-chlorophenyl)carbamate 
• 1190762-10-7 C₉H₉ClN₄O 
• 1190762-09-4 tert-butyl-4-chlorophenyl(3-hydrazinyl-3-oxopropyl)carbamate 
• 1362017-54-6 methyl N-tosyl-3-(4-chloroanilino)propionate 
• 2903-34-6 4-methyl-N-(4-chlorophenyl)benzenesulfonamide 
• 1422186-31-9 1-tosyl-4,4-dimethyl-6-chloro-1,2,3,4-tetrahydroquinoline 
• 1422186-19-3 N-tosyl-4-(4-chloroanilino)-2-methyl-2-butanol 
• 1190762-03-8 methyl 3-(tert-butoxycarbonyl-(4-chlorophenyl)amino)propanoate 
• 1014697-59-6 methyl 3-[(4-chloro-2-iodophenyl)amino]propionate 
• 18042-96-1 3-[(2-Acetylamino-5-chloro-benzyl)-(4-chloro-phenyl)-amino]-propionic acid 

Relevant articles and documents

Apixaban intermediate and preparation method thereof

The embodiment of the invention discloses an apixaban intermediate and a preparation method thereof. The preparation method comprises the following steps: preparation of an intermediate 2, preparationof an intermediate 3, preparation of an intermediate 4, preparation of an intermediate 5, and preparation of apixaban key intermediate 5, 6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidyl) phenyl]-2 (1H)-pyridone. According to the apixaban intermediate 5, 6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidyl) phenyl]-2 (1H)-pyridone and the preparation method thereof provided by the invention, the operation is simple, the reaction condition is mild, the requirement on equipment is low, scale-up production is easier, the yield is high, and the purity of the product is greater than 99%.

Polymer coated magnetically separable organocatalyst for C[sbnd]N bond formation via aza-Michael addition

A polyacrylamide coated magnetite (PAM@MNP) catalyst was synthesized by following a two step approach involving the reaction of magnetite (Fe3O4) particles with coupling agent 3-(trimethoxysilyl)propyl methacrylate followed by grafting of acrylamide and subsequent polymerization via surface initiated radical polymerization technique. The synthesized organocatalyst was used for a one-pot aza-Michael addition reaction of amines with electron deficient alkenes to give β-amino carbonyls. The magnetic properties of the synthesized organocatalyst provide it a facile recovery by external magnet which eliminates the problems arising during catalyst separation by conventional filtration.

Tetrahydroquinolines by lewis acid-promoted friedel-crafts cyclizations

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