219138-02-0

Basic information

• Product Name: Z-IETD-AFC
• Synonyms: Z-ILE-GLU-THR-ASP-AFC;Z-IETD-AFC;N-CBZ-ILE-GLU-THR-ASP 7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN;CBZ-IETD-AFC;CASPASE-8 SUBSTRATE II;CASPASE 8 SUBSTRATE 1F-Z, FLUOROGENIC;CASPASE-8, SUBSTRATE, FLUOROGENIC;GRANZYME B SUBSTRATE II, FLUOROGENIC
• CAS NO: 219138-02-0
• Molecular Formula: C37H42F3N5O13
• Molecular Weight: 821.75
• Product Categories: peptide;Pepetides
• Mol File: 219138-02-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: Z-IETD-AFC(CAS DataBase Reference)
• NIST Chemistry Reference: Z-IETD-AFC(219138-02-0)
• EPA Substance Registry System: Z-IETD-AFC(219138-02-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 219138-02-0(Hazardous Substances Data)

Usage

General Description

Z-IETD-AFC is a synthetic peptide derivative that functions as a fluorogenic substrate for caspase-8, a cysteine protease involved in programmed cell death. When cleaved by caspase-8, Z-IETD-AFC releases a fluorescent AFC (7-amino-4-trifluoromethylcoumarin) compound, allowing for the real-time detection and measurement of caspase-8 activity in vitro. Z-IETD-AFC has been widely used in research to study the mechanisms of apoptosis and the role of caspase-8 in various physiological and pathological processes, such as cancer, autoimmune diseases, and neurodegenerative disorders. Its use has provided valuable insights into the regulation and function of caspase-8, aiding in the development of potential therapeutic interventions targeting this pathway.