219297-11-7

Basic information

• Product Name: BOC-(S)-3-AMINO-4-(2-NAPHTHYL)-BUTYRIC ACID
• Synonyms: N-T-BUTOXYCARBONYL-(S)-3-AMINO-4-(2-NAPHTHYL)BUTANOIC ACID;N-BETA-T-BUTOXYCARBONYL-L-HOMO(2-NAPHTHYL)ALANINE;Boc-(S)-3-amino-4-(2-naphenyl)butanoic acid;boc-4-(2-naphthyl)-l-β-homoalanine;BOC-(S)-2-AMINO-4-(2-NAPHTHYL)-BUTYRIC ACID;Boc-b-HoAla(2-naphthyl)-OH;Boc-β-2-Homonal-OH, Boc-4-(2-naphthyl)-L-β-homoalanine;BOC-(S)-3-AMINO-4-(2-NAPHTHYL)BUTANOIC ACID
• CAS NO: 219297-11-7
• Molecular Formula: C19H23NO4
• Molecular Weight: 329.39
• Product Categories: 3-Amino-4-phenylbutyric Acid Analogs;3-Amino-4-phenylbutanoic Acid Analogs;B-Amino
• Mol File: 219297-11-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 527.932 °C at 760 mmHg
• Flash Point: 273.084 °C
• Appearance: /
• Density: 1.179
• Vapor Pressure: 5.65E-12mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: 2-8°C
• PKA: 4.42±0.10(Predicted)
• CAS DataBase Reference: BOC-(S)-3-AMINO-4-(2-NAPHTHYL)-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-(S)-3-AMINO-4-(2-NAPHTHYL)-BUTYRIC ACID(219297-11-7)
• EPA Substance Registry System: BOC-(S)-3-AMINO-4-(2-NAPHTHYL)-BUTYRIC ACID(219297-11-7)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 10
• HazardClass: IRRITANT
• Hazardous Substances Data: 219297-11-7(Hazardous Substances Data)

Usage

General Description

Boc-(S)-3-amino-4-(2-naphthyl)-butyric acid is a chemical compound commonly used in the field of organic chemistry. It is a derivative of 3-amino-4-(2-naphthyl)-butyric acid, with the addition of a Boc (tert-butyloxycarbonyl) protecting group at the amine functional group. Boc-(S)-3-amino-4-(2-naphthyl)-butyric acid is often used as a building block in the synthesis of various pharmaceuticals and bioactive molecules due to its unique structural properties. It is a chiral compound, with the (S)-enantiomer being the more commonly used form in organic synthesis. Boc-(S)-3-amino-4-(2-naphthyl)-butyric acid is commonly utilized in the development of new drugs and in the study of medicinal chemistry due to its potential biological activity.

InChI:InChI=1/C19H23NO4/c1-19(2,3)24-18(23)20-16(12-17(21)22)11-13-8-9-14-6-4-5-7-15(14)10-13/h4-10,16H,11-12H2,1-3H3,(H,20,23)(H,21,22)/t16-/m0/s1

Relevant articles and documents

Synthesis method of chiral N-Boc-3-amino-4-aryl-butyric acid

The invention relates to a synthesis method of chiral N-Boc-3-amino-4-aryl-butyric acid. The method is as below: 1, conducting a cross metathesis reaction, an asymmetric conjugate addition reaction and an oxidation reaction on starting materials including an allyl aromatic compound and crotonaldehyde by a continuous reaction one-pot method to synthesize an N-Boc-3-aryl methyl-5-oxo isoxazole intermediate; or conducting an asymmetric conjugate addition reaction and an oxidation reaction on a starting material (E)-4-aryl-2-crotonaldehyde by a continuous reaction one-pot method to synthesize an N-Boc-3-aryl methyl-5-oxo isoxazole intermediate; and 2, subjecting (3R)-N-Boc-3-aryl methyl-5-oxo isoxazole intermediate by high-pressure hydrogenation to directly prepare the chiral N-Boc-3-amino-4-aryl-butyric acid. The synthesis method provided by the invention has the advantages of simple operation, mild reaction conditions, target product yield reaching 60-69%, and ee value of the target product reaching as high as 96%. The synthetic route has industrialization prospect.