21969-05-1

Basic information

• Product Name: 1-(4-Iodophenoxy)-4-nitrobenzene
• Synonyms: 1-(4-Iodophenoxy)-4-nitrobenzene;(4-Iodophenoxy)-4-nitrobenzene;(4-Iodophenoxy)-4-nitrobenzene 95%;1-IODO-4-(4-NITROPHENOXY)BENZENE
• CAS NO: 21969-05-1
• Molecular Formula: C₁₂H₈INO₃
• Molecular Weight: 341.10129
• Mol File: 21969-05-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-Iodophenoxy)-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Iodophenoxy)-4-nitrobenzene(21969-05-1)
• EPA Substance Registry System: 1-(4-Iodophenoxy)-4-nitrobenzene(21969-05-1)

Safety Data

• Hazardous Substances Data: 21969-05-1(Hazardous Substances Data)

Usage

Physical state

Yellow crystalline solid

Usage

Building block in the synthesis of pharmaceuticals and agrochemicals

Contains

Nitro group and iodophenoxy group

Application

Organic synthesis reagent

Additional uses

Manufacture of dyes, pigments, and specialty chemicals

Toxicity

Moderate toxicity

Handling

Should be handled with care in a controlled laboratory setting

Upstream product

• 620-88-2 4-nitrophenyl phenyl ether 
• 2974-94-9 4-phenoxyiodobenzene 
• 540-38-5 p-Iodophenol 
• 350-46-9 4-Fluoronitrobenzene 
• 100-02-7 4-nitro-phenol 
• 352-34-1 4-fluoro-1-iodobenzene 
• 101-84-8 diphenylether 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 856704-53-5 4-(4'-nitrophenoxy)phenylacetylene 
• 28896-49-3 bis(4-iodophenyl) ether 
• 58518-73-3 4-(4-iodo-phenoxy)-aniline 
• 1244974-58-0 4-(4-nitrophenoxy)-(trifluoromethylthio)benzene 

Relevant articles and documents

CsF/clinoptilolite: An efficient solid base in SNAr and copper-catalyzed Ullmann reactions

CsF/clinoptilolite was found to be an efficient solid base catalyst for both SNAr and Ullmann ether reactions. A general and efficient one-step procedure was developed for the synthesis of biaryl ethers via direct coupling of electron-deficient aryl halides to phenols using CsF/clinoptilolite. The protocol was also applied to electron-rich aryl halides by addition of a catalytic amount of copper oxide nanoparticles. Both SNAr and Ullmann reactions were rapid and provided good to excellent yields.

Ligand-free solid supported palladium(0) nano/microparticles promoted C-O, C-S, and C-N cross coupling reaction

Ligand-free solid-supported nano and microparticles of Pd(0) (SS-Pd) were used as a heterogeneous catalyst in carbon-heteroatom bond formation reactions. Nitro substituted aryl halides reacted with oxygen, sulfur, and nitrogen nucleophiles to afford the corresponding products in good yields. A one-pot sequential cross coupling and nitro-reduction was also performed using the same SS-Pd catalyst to access amine substituted carbon-heteroatomic molecules. In addition, SS-Pd could be recycled up to seven runs without a significant loss of catalytic activity.

METHODS AND COMPOSITIONS FOR MODULATING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ACTIVITY

The present invention relates to compounds which modulate the activity of the SI P1 receptor, the use of these compounds for treating conditions associated with signaling through the S1 P1 receptor, and pharmaceutical compositions comprising these compounds.