220-11-1Relevant articles and documents
The acetal concept: Regioselective access to ortho,ortho-diphenols via dibenzo-1,3-dioxepines
Masters, Kye-Simeon,Br?se, Stefan
, p. 866 - 869 (2013/02/26)
Traditional methods are ill-suited for the synthesis of ortho,ortho-biphenols, a structural motif found in many polyphenolic natural products, as well as synthetically useful compounds such as the chiral ligands binol, vapol, and vanol. The new route consists of a radical-based reaction of an acetal-tethered biphenyl ether substrate and subsequent hydrolytic cleavage of the dibenzo-1,3-dioxepine intermediate. Copyright